Description
Diclofenak (Diclofenac) Gel 50 mg/g, 40 g Tube
Composition
Diclofenak gel contains 50 mg of diclofenac per gram. The gel formulation also includes inactive ingredients such as carbomer, cocoyl caprylocaprate, isopropyl alcohol, liquid paraffin, perfume cream 45, propylene glycol, and purified water.
Mechanism of Action
Diclofenak gel exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins involved in inflammation and pain.
Pharmacological Properties
Diclofenac in Diclofenak gel possesses anti-inflammatory, analgesic, and antipyretic properties, making it effective in managing pain and inflammation associated with musculoskeletal conditions.
Indications for Use
- Relief of pain and inflammation in arthritis
- Treatment of sprains and strains
- Management of backache
Contraindications
Avoid using Diclofenak gel if allergic to diclofenac or any other ingredients in the gel. Do not apply to broken or irritated skin.
Side Effects
Common side effects may include skin irritation, redness, or rash at the application site. Discontinue use if any adverse reactions occur.
Usage Instructions
Apply a thin layer of Diclofenak gel to the affected area 3-4 times a day. Gently massage into the skin. Wash hands after application unless treating the hands.
Benefits Compared to Analogues
The topical formulation of diclofenac in Diclofenak gel offers localized pain relief with lower systemic exposure compared to oral diclofenac, reducing the risk of systemic side effects.
Suitable Patient Groups
Diclofenak gel is suitable for adults, including the elderly, for the management of musculoskeletal pain and inflammation. Use in children should be under medical supervision.
Storage and Shelf Life
Store Diclofenak gel at room temperature, away from moisture and heat. Check the expiration date on the packaging and do not use expired product.
Packaging Description
The gel is packaged in a 40 g tube for convenient topical application. The tube is designed for easy squeezing and dispensing of the gel.
Clinical Evidence and Proven Effectiveness
Studies have shown that topical diclofenac formulations like Diclofenak gel provide effective pain relief with lower systemic exposure compared to oral diclofenac. Research published in the Journal of Pain Research demonstrated the efficacy of diclofenac gel in managing osteoarthritis pain. Clinical trials have also shown significant improvements in pain scores and physical function in patients with musculoskeletal conditions treated with diclofenac gel.
