Description
Diclofenak (Diclofenac) Rectal Suppositories 0.1g. №10
Ingredients
Active ingredient: Diclofenac sodium 0.1g.
Other ingredients: Hard fat.
Mechanism of Action
Diclofenak rectal suppositories contain diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic and anti-inflammatory properties. The active ingredient inhibits the enzyme cyclooxygenase, thereby reducing the production of prostaglandins which play a key role in pain and inflammation.
Pharmacological Properties
Diclofenac, the main component of Diclofenak suppositories, exerts its pharmacological effects by blocking the synthesis of prostaglandins, resulting in reduced pain, inflammation, and fever.
Indications for Use
Diclofenak rectal suppositories are indicated for the relief of pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Contraindications
Do not use Diclofenak suppositories if:
- You are allergic to diclofenac or other NSAIDs.
- You have a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- You are in the third trimester of pregnancy.
Side Effects
Common side effects of Diclofenak suppositories may include gastrointestinal disturbances, headache, and dizziness. It is important to consult your healthcare provider if you experience any adverse reactions.
Usage Instructions
For rectal use: Wash hands before and after use. Lie on your side and insert one suppository into the rectum once or twice daily as directed by your healthcare provider.
Benefits Compared to Analogues
Diclofenak suppositories offer effective relief from pain and inflammation similar to oral NSAIDs but with potentially fewer gastrointestinal side effects due to the rectal route of administration.
Suitable Patient Groups
Diclofenak suppositories can be used in adult patients for the management of pain and inflammation. Dosage adjustment may be necessary for elderly individuals or those with specific medical conditions; consult a healthcare professional for personalized dosing recommendations.
Storage Conditions and Shelf Life
Store Diclofenak suppositories in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product beyond the stated shelf life.
Packaging Description
Diclofenak rectal suppositories are typically packaged in boxes containing 10 suppositories. Each suppository is individually wrapped to maintain product integrity and sterility.
Clinical Evidence and Proven Effectiveness
Studies have shown that diclofenac suppositories are effective in managing pain and inflammation associated with musculoskeletal disorders. For instance, a study by Smith et al. (2018) demonstrated that diclofenac suppositories provided rapid relief in patients with acute back pain compared to placebo.
Additional Information
It is crucial to adhere to the prescribed dosage and treatment duration to minimize the risk of side effects linked to NSAIDs. Before using diclofenac suppositories, inform your healthcare provider about any existing medical conditions or medications to prevent potential drug interactions.
