Description
Diclofenak (Diclofenac) Rectal Suppositories 100 mg. №10
Ingredients
Active ingredient: Diclofenac sodium 100 mg. Other ingredients: Hard fat.
Mechanism of Action
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic, anti-inflammatory, and antipyretic properties. It functions by inhibiting the enzyme cyclooxygenase, thereby reducing the synthesis of prostaglandins which are mediators of pain and inflammation.
Pharmacological Properties
Diclofenac exerts its pharmacological effects through the inhibition of prostaglandin synthesis, leading to decreased inflammation, pain relief, and fever reduction.
Indications for Use
Diclofenak rectal suppositories are indicated for the management of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
Contraindications
Do not use Diclofenak suppositories if you:
- Have a history of allergic reactions to diclofenac or other NSAIDs.
- Are in the third trimester of pregnancy.
- Have active peptic ulcers.
Side Effects
Common side effects of diclofenac suppositories may include gastrointestinal discomfort, headache, dizziness, and skin reactions. In rare cases, severe allergic reactions or gastrointestinal bleeding may occur.
Usage Instructions
For rectal use only. Wash hands before and after use. Lie on your side and gently insert one suppository into the rectum once or twice daily as directed by a healthcare professional.
Benefits Compared to Analogues
Diclofenac suppositories offer localized treatment with potentially faster onset of action compared to oral formulations, making them advantageous for individuals who may have difficulty swallowing or require rapid pain relief.
Suitable Patient Groups
Diclofenac suppositories are suitable for adults, including the elderly, who require targeted relief from pain and inflammation in musculoskeletal conditions. The dosage may need adjustment in patients with renal or hepatic impairment.
Storage Conditions and Shelf Life
Store diclofenac suppositories in a cool, dry place below 25°C. Keep them out of reach of children. Check the expiry date on the packaging and do not use the product after the stated shelf life has passed.
Packaging Description
Diclofenak rectal suppositories are typically packaged in blister packs to maintain product integrity and ensure individual dosing convenience. Each pack contains 10 suppositories.
Scientific Evidence
Diclofenac is supported by clinical evidence demonstrating its efficacy in managing pain and inflammation. A study published in the Journal of Rheumatology highlighted the rapid and effective relief provided by diclofenac suppositories compared to oral formulations, emphasizing its role in musculoskeletal conditions.
Additional Information
It is crucial to adhere to the prescribed dosage and treatment duration to minimize the risk of adverse effects. If you encounter severe side effects or allergic reactions, discontinue use and seek medical advice promptly. Prior consultation with a healthcare provider is recommended, especially for individuals with comorbidities or those on multiple medications.
