Description

Difors 80 (amlodipine besilate and valsartan) Coated Tablets 5 mg/80 mg. №30

Ingredients:

Each tablet contains 5 mg of amlodipine besilate and 80 mg of valsartan.

Dosage:

The recommended dosage is one tablet per day, or as directed by a healthcare professional.

Indications:

Difors 80 tablets are indicated for the treatment of hypertension in patients not adequately controlled with monotherapy.

Contraindications:

Do not use Difors 80 if you are pregnant, have severe liver disease, or are allergic to any of the components in the tablets.

Directions:

Swallow the tablet whole with water, with or without food, at the same time each day.

Scientific Evidence:

Studies have shown that the combination of amlodipine besilate and valsartan in Difors 80 tablets provides a synergistic effect in lowering blood pressure. A randomized controlled trial published in the Journal of Hypertension demonstrated that this combination therapy was more effective in reducing both systolic and diastolic blood pressure compared to monotherapy with either drug alone.

Additional Information:

Difors 80 tablets offer the convenience of a single pill combination therapy for patients with hypertension, potentially improving medication adherence. Clinical trials have also indicated that the side effect profile of the combination is similar to that of the individual components, with no significant additional adverse effects reported.

The pharmacological action of amlodipine involves the inhibition of calcium ion influx across cell membranes, leading to vasodilation and decreased peripheral vascular resistance. Valsartan, on the other hand, is an angiotensin II receptor blocker that works by blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II, further reducing blood pressure.