Description
Dinastat (Parecoxib) Powder for Infusions 40 mg Vial №5
Ingredients:
Each vial contains 40 mg of parecoxib.
Mechanism of Action:
Parecoxib, the active ingredient in Dinastat, is a prodrug of valdecoxib, a selective COX-2 inhibitor. By inhibiting COX-2, parecoxib suppresses the production of prostaglandins, which are mediators of pain and inflammation.
Pharmacological Properties:
Dinastat exerts analgesic, anti-inflammatory, and antipyretic effects through its action on the COX-2 enzyme pathway.
Indications for Use:
Dinastat is indicated for the relief of acute postoperative pain in adult patients.
Contraindications:
Do not use Dinastat in patients with known hypersensitivity to parecoxib, other NSAIDs, or history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Side Effects:
Common side effects of Dinastat may include nausea, vomiting, constipation, headache, dizziness, and injection site reactions. Serious side effects such as gastrointestinal bleeding, renal impairment, and hypersensitivity reactions may occur rarely.
Usage Instructions:
The recommended dose of Dinastat is 40 mg administered by intravenous infusion over 15 minutes every 12 hours. Dosage adjustments may be necessary based on individual patient factors.
Benefits Compared to Analogues:
Dinastat offers a favorable gastrointestinal safety profile compared to non-selective NSAIDs, making it a preferred choice in patients at risk of gastrointestinal complications. Its selective COX-2 inhibition provides effective pain relief with reduced risk of adverse effects.
Suitable Patient Groups:
Dinastat is suitable for adult patients requiring acute postoperative pain management. It is not recommended for use in pediatric populations, pregnant women, or individuals with a history of severe cardiovascular events.
Storage Conditions and Shelf Life:
Store Dinastat vials in a cool, dry place away from direct sunlight. Do not freeze. Check the expiration date on the packaging and do not use expired product.
Packaging Description:
Dinastat is supplied in vials containing 40 mg of parecoxib powder for reconstitution. Each package includes 5 vials for multiple doses.
Clinical Evidence and Proven Effectiveness:
Studies have shown that parecoxib effectively reduces postoperative pain and opioid consumption, making it a valuable option in acute pain management following surgery. Clinical trials have demonstrated the efficacy and safety of Dinastat in adult patients, supporting its use in postoperative care.
