Description

Diocor 160 (Valsartan, Hydrochlorothiazide) Coated Tablets 160 mg/12.5 mg. №10

Ingredients

Diocor 160 tablets contain 160 mg of valsartan and 12.5 mg of hydrochlorothiazide. Valsartan is an angiotensin II receptor antagonist, while hydrochlorothiazide is a thiazide diuretic. These two ingredients work together to lower blood pressure by different mechanisms.

Dosage

The recommended dosage of Diocor 160 is one tablet once daily. It is important to follow the instructions provided by your healthcare provider for the best results. Do not exceed the prescribed dose unless directed by a doctor.

Indications

Diocor 160 tablets are indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled by monotherapy. It is used to lower the risk of cardiovascular events such as stroke and heart attack.

Contraindications

Do not take Diocor 160 if you are allergic to any of the ingredients, if you are pregnant, or if you have severe liver or kidney disease. It is important to discuss your medical history with your doctor before starting this medication.

Directions

Take Diocor 160 tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with a glass of water. It can be taken with or without food, but consistency is key for optimal results.

Scientific Evidence

Studies have shown that the combination of valsartan and hydrochlorothiazide in Diocor 160 tablets is effective in lowering blood pressure. A meta-analysis published in the Journal of Hypertension demonstrated that this combination therapy is more effective than monotherapy in reducing both systolic and diastolic blood pressure levels.

Additional Information

It is important to monitor your blood pressure regularly while taking Diocor 160 tablets. Some common side effects may include dizziness, lightheadedness, or increased urination. If you experience any severe side effects, contact your healthcare provider immediately.

Pharmacological Effects: Valsartan works by blocking the action of angiotensin II, a hormone that constricts blood vessels, leading to vasodilation and decreased blood pressure. Hydrochlorothiazide acts on the kidneys to increase the excretion of sodium and water, further reducing blood volume and pressure.

Clinical Trials: In a randomized controlled trial published in the New England Journal of Medicine, the combination of valsartan and hydrochlorothiazide was compared to other antihypertensive agents. The study found that the valsartan-hydrochlorothiazide combination was well-tolerated and effective in lowering blood pressure.