Description
Dorez (Bisoprolol) Tablets 10 mg. №30
Composition
Each tablet contains 10 mg of bisoprolol.
Mechanism of Action
Bisoprolol, the active ingredient in Dorez tablets, is a selective beta-blocker that works by blocking the action of adrenaline on the heart. This results in a reduction of heart rate and blood pressure, making it an effective treatment for various cardiovascular conditions.
Pharmacological Properties
Bisoprolol is a beta-1 selective adrenergic receptor blocker. It reduces the heart rate and cardiac output by blocking beta-1 receptors in the heart, leading to decreased oxygen demand and improved myocardial oxygen supply-demand balance.
Indications for Use
Dorez tablets are indicated for the treatment of hypertension, angina pectoris, and heart failure.
Contraindications
Do not use Dorez tablets if you have a known hypersensitivity to bisoprolol or other beta-blockers. Patients with certain cardiac conditions such as bradycardia, heart block, or cardiogenic shock should also avoid using this medication.
Side Effects
Common side effects of Dorez tablets may include fatigue, dizziness, and cold extremities. In some cases, patients may experience bradycardia, hypotension, or exacerbation of heart failure symptoms. It is essential to consult a healthcare provider if any severe adverse reactions occur.
Usage Instructions
The recommended dosage of Dorez tablets is one 10 mg tablet taken orally once daily. The tablets should be swallowed whole with a glass of water and should not be crushed or chewed. Dosage adjustments may be necessary based on individual patient response and underlying medical conditions.
Benefits Compared to Analogues
Dorez tablets offer the advantage of once-daily dosing with a well-established safety profile and proven efficacy in the management of hypertension, angina, and heart failure. Compared to non-selective beta-blockers, bisoprolol has a lower risk of bronchospasm in patients with respiratory conditions such as asthma or chronic obstructive pulmonary disease.
Suitable Patient Groups
Dorez tablets are suitable for adult patients with hypertension, angina, or heart failure. Special caution should be exercised when prescribing this medication to elderly patients or those with renal impairment. Pediatric use of bisoprolol should be under the supervision of a pediatric cardiologist.
Storage and Shelf Life
Dorez tablets should be stored at room temperature away from moisture and heat. The shelf life of the product is typically 2-3 years from the manufacturing date. Do not use the tablets after the expiration date printed on the packaging.
Packaging Description
Dorez tablets are typically packaged in blister packs of 30 tablets each. The packaging is designed to protect the tablets from light and moisture, ensuring their stability and potency until the expiration date.
Scientific Evidence
Several studies have demonstrated the efficacy of bisoprolol in the management of hypertension and heart failure. A study published in the European Heart Journal showed that bisoprolol significantly reduced the risk of cardiovascular events in patients with heart failure. Clinical trials have also shown the benefits of bisoprolol in improving exercise tolerance and reducing hospitalizations in patients with chronic heart failure.
Additional Information
- Pregnancy and Lactation: Consult your healthcare provider before using Dorez tablets if you are pregnant or breastfeeding to assess the potential risks and benefits of treatment.
- Monitoring: Regular monitoring of blood pressure, heart rate, and electrolyte levels is recommended during treatment with Dorez tablets to ensure optimal therapeutic outcomes and early detection of adverse effects.
