Dorez (bisoprolol) tablets 10 mg. №30

Description

Dorez 10 mg Storage
active substance: bisoprolol (bisoprolol);

1 film-coated tablet contains bisoprolol fumarate 5 mg or 10 mg;

Dorez 10 mg excipients: siliconized microcrystalline cellulose (microcrystalline cellulose 98% / colloidal anhydrous silica 2%); crospovidone; glycerol dibegenate;

shell:

5 mg tablets – Opadry yellow 02B32859 (hypromellose, macrogol 400, titanium dioxide (E 171), iron oxide yellow (E 172));

10 mg tablets – Opadry yellow 02F32202 (hypromellose, macrogol 400, titanium dioxide (E 171), iron oxide yellow (E 172)).

Dorez 10 mg Dosage form
Film-coated tablets.

Basic physical and chemical properties:

5 mg tablets: round biconvex, film-coated yellow tablets, scored on one side;

10 mg tablets: round biconvex, film-coated tablets of ocher-yellow color, with a line on one side.

Pharmacotherapeutic group
Selective beta-blockers.

ATX code C07A B07.

Pharmacological properties

Pharmacodynamics.

Bisoprolol is a potent selective beta1-blocker, without its own sympathomimetic activity, has no membrane-stabilizing effect.

The mechanism of its antihypertensive action is unclear, but it is known that bisoprolol significantly reduces the level of renin in blood plasma.

In patients with angina, blockade of beta1-receptors leads to a decrease in cardiac activity and, consequently, to a decrease in myocardial oxygen demand. Effective in the treatment of stable chronic moderate and severe heart failure with reduced ventricular systolic function.

Pharmacokinetics.

Bisoprolol is almost completely absorbed from the gastrointestinal tract. Due to the slight metabolism during the first passage through the liver, it can be concluded that bisoprolol has a high bioavailability. Eating does not affect the absorption of bisoprolol.

There are no active metabolites.

The drug is excreted equally through the liver and kidneys. The half-life from blood plasma (10-12 hours) provides efficiency within 24 hours after reception 1 time a day.

Indication
Hypertension;
coronary heart disease (angina);
chronic heart failure with left ventricular systolic dysfunction in combination with ACE inhibitors, diuretics, and, if necessary, cardiac glycosides.

Contraindication
Acute heart failure or heart failure in the stage of decompensation that requires inotropic therapy;
cardiogenic shock;
atrioventricular block II and III degree (except for that in patients with an artificial pacemaker);
sinus node weakness syndrome;
sinoatrial block;
symptomatic bradycardia;
symptomatic hypotension;
severe asthma;
late stages of peripheral circulatory disorders or Raynaud’s disease;
untreated pheochromocytoma;
metabolic acidosis;
hypersensitivity to bisoprolol or to other components of the drug.