Description
Doxepin (Doxepin) Capsules 10 mg. №30
Composition
Each capsule contains 10 mg of doxepin hydrochloride.
Mechanism of Action
Doxepin, a tricyclic antidepressant, functions by inhibiting the reuptake of serotonin and norepinephrine in the brain. This mechanism aids in restoring the balance of these neurotransmitters, which play a crucial role in mood and emotion regulation.
Pharmacological Properties
Doxepin exerts its therapeutic effects through its actions on neurotransmitter reuptake, particularly serotonin and norepinephrine. It also exhibits antagonistic effects on certain receptors, contributing to its pharmacological profile.
Indications for Use
Doxepin is indicated for the treatment of depression and anxiety disorders.
Contraindications
Avoid using doxepin if you have a history of hypersensitivity to tricyclic antidepressants. It is important to discuss any known allergies with your healthcare provider before initiating doxepin therapy.
Side Effects
Common side effects of doxepin may include drowsiness, dry mouth, constipation, blurred vision, and weight gain. Contact your healthcare provider if you experience any persistent or severe side effects while taking doxepin.
Usage Instructions
The typical initial dose is 25 mg taken orally at bedtime. Dosage adjustments should be made gradually based on individual response and tolerability. It is essential to adhere to the dosage regimen prescribed by your healthcare provider and avoid abrupt discontinuation of the medication.
Benefits Compared to Analogues
Doxepin offers advantages over some analogues due to its established efficacy in managing depression and anxiety disorders. Its unique pharmacological profile and tolerability profile make it a valuable option in the treatment of these conditions.
Suitable Patient Groups
Doxepin can be used in various patient populations, including adults, elderly individuals, and certain pediatric cases under close medical supervision. Dosage adjustments may be necessary in specific age groups to optimize treatment outcomes.
Storage and Shelf Life
Store doxepin capsules in a cool, dry place away from direct sunlight. Adhere to the recommended storage conditions provided on the packaging. Check the expiration date and do not use expired medication.
Packaging Description
Doxepin capsules are typically packaged in blister packs or amber-colored containers to protect the medication from light degradation. Each package contains a specific number of capsules as indicated by the product label.
Clinical Evidence and Proven Effectiveness
Several studies have demonstrated the efficacy of doxepin in treating depression and anxiety disorders. Notably, a meta-analysis published in the Journal of Clinical Psychiatry highlighted doxepin’s superior efficacy compared to placebo in alleviating depressive symptoms.
