Eczifin (terbinafine) gel 1% 15 g. tube №1

Description

Eczifin Composition
active substance: terbinafine;

1 g of gel contains 10 mg terbinafine;

Eczifin excipients: isopropyl myristate, butylhydroxytoluene (E 321), benzyl alcohol, sorbitan laurate, polysorbate 20, carbomer 974R, sodium hydroxide, sodium edetate, ethanol, purified water.

Eczifin Dosage form
Gel.

Basic physical and chemical properties: from white to almost white, homogeneous gel without visible impurities.

Pharmacotherapeutic group
ATX code D01A E15. Antifungal drugs for topical use.

Pharmacodynamics
Terbinafine is an allylamine and has a broad spectrum of antifungal action against skin infections caused by dermatophytes such as Trichophyton (e.g. T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum. Terbinafine in low concentrations has a fungicidal effect against dermatophytes and molds. Activity against yeast is fungicidal (eg Pityrosporum orbiculare or Malassezia furfur) or fungistatic depending on the species.

Terbinafine specifically inhibits the early stage of sterol biosynthesis in the fungal cell membrane. This leads to a deficiency of ergosterol and intraclitin accumulation of squalene, which causes the death of the fungal cell. The influence of terbinafine is carried out by inhibiting the enzyme squalene epoxidase in the cell membrane of the fungus. This enzyme does not belong to the cytochrome P450 system. Terbinafine does not affect the metabolism of hormones or other drugs.

Terbinafine has long-term effects in the treatment of athlete’s foot. In most patients, after 1 week of treatment, there was no relapse or reinfection within 2 months after stopping treatment.

Pharmacokinetics
When applied externally, less than 5% of the dose is absorbed, therefore, the absorption of terbinafine into the systemic circulation is negligible.

The fungicidal concentration of terbinafine, which is present in the stratum corneum of the epidermis after 7 days of using the drug, persists for up to 7 days after stopping treatment. The effect of terbinafine on the ability to fertilize in animals was not observed.

Indications
Fungal skin infections caused by dermatophytes such as Trichophyton (eg T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum, eg athlete’s foot (athlete’s foot), groin dermatophytosis ( “Jockey’s itch”), dermatophytosis of the trunk (“ringworm”). Lichen, caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Contraindications
Hypersensitivity to terbinafine or to any of the components of the drug.

Interaction with other medicinal products and other forms of interaction
Interaction is unknown, however, as a precautionary measure, do not apply other drugs to the treated area.