Description
Enalapril (Enalapril) Tablets 20 mg. №20
Ingredients
Enalapril (as enalapril maleate) 20 mg
Mechanism of Action
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that functions by blocking the conversion of angiotensin I to angiotensin II. This action leads to vasodilation, decreased peripheral resistance, and lowered blood pressure.
Pharmacological Properties
Following oral administration, Enalapril is rapidly absorbed and converted to its active metabolite, enalaprilat. It exhibits a suitable half-life for once-daily dosing and is primarily eliminated via renal excretion.
Indications for Use
Enalapril is prescribed for hypertension management to reduce blood pressure and lower the risk of cardiovascular events. Additionally, it is indicated for heart failure treatment to ameliorate symptoms and reduce hospitalizations.
Contraindications
Enalapril is contraindicated in pregnant women due to potential fetal harm. Patients with a history of angioedema from previous ACE inhibitor use should avoid Enalapril. Individuals with known hypersensitivity to Enalapril or its components should not use this medication.
Side Effects
Common side effects of Enalapril include dizziness, dry cough, hypotension, and hyperkalemia. Rare but severe adverse effects may comprise angioedema, renal dysfunction, and neutropenia. Patients should promptly seek medical attention for any serious reactions.
Usage Instructions
The standard dosage of Enalapril is 20 mg orally once daily. Healthcare providers may adjust the dosage based on individual response and tolerability. The tablets should be swallowed whole with a full glass of water.
Benefits Compared to Analogues
Enalapril has exhibited efficacy in various clinical trials, demonstrating significant blood pressure reductions and enhanced outcomes in heart failure. Its once-daily dosing schedule and established safety profile render it preferable to some other ACE inhibitors.
Suitable Patient Groups
Enalapril is generally well-tolerated across different age groups, including children and the elderly. However, patients with renal impairment or specific medical conditions may require dosage adjustments. Close monitoring, especially during initial treatment stages, is advisable for all patients.
Storage Conditions and Shelf Life
Enalapril tablets should be stored at room temperature, shielded from moisture and heat. Adherence to the indicated shelf life on the packaging is crucial for optimal efficacy.
Packaging Description
The packaging of Enalapril tablets typically includes details such as product name, dosage strength, quantity, manufacturer information, and expiration date. It may also provide instructions for use and potential side effects.
Clinical Evidence and Proven Effectiveness
Enalapril has undergone extensive clinical trials, illustrating its efficacy in reducing blood pressure and enhancing cardiac function in hypertensive and heart failure patients. Studies have indicated that Enalapril is linked to reduced mortality and morbidity rates in these patient cohorts.
