Description
Enalapril (enalapril) Tablets 5 mg. №30
Composition
Each tablet contains 5 mg of enalapril maleate as the active ingredient.
Mechanism of Action
Enalapril, an angiotensin-converting enzyme (ACE) inhibitor, acts by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By blocking this enzyme, enalapril promotes vasodilation, reduces aldosterone secretion, and ultimately decreases peripheral resistance, leading to lowered blood pressure and improved cardiac output.
Pharmacological Properties
Enalapril, an ACE inhibitor, exerts its pharmacological effects by inhibiting the renin-angiotensin-aldosterone system. It dilates blood vessels, reduces the production of aldosterone, and decreases sodium and water retention, all contributing to its antihypertensive and cardioprotective properties.
Indications for Use
Enalapril is indicated for the management of hypertension to lower blood pressure, for the treatment of heart failure to improve cardiac function, and for the enhancement of survival post-myocardial infarction.
Contraindications
Avoid enalapril if you are pregnant, have a history of angioedema associated with ACE inhibitors, or are known to be allergic to ACE inhibitors. Use with caution in patients with bilateral renal artery stenosis or renal impairment.
Side Effects
Common side effects of enalapril may include dizziness, dry cough, hypotension, and hyperkalemia. Severe adverse reactions such as angioedema and renal impairment are rare but require immediate medical attention.
Usage Instructions
The recommended initial dose of enalapril is 5 mg once daily. Dosage adjustments may be made by your healthcare provider based on individual response. Swallow the tablet whole with water, with or without food. Do not discontinue treatment abruptly without consulting your physician.
Benefits Compared to Analogues
Enalapril demonstrates comparable efficacy to other ACE inhibitors in managing hypertension and heart failure. It may offer advantages in terms of cost-effectiveness and once-daily dosing convenience, enhancing patient adherence to therapy.
Suitable Patient Groups
Enalapril is suitable for adult patients, including the elderly population, for the management of hypertension and heart failure. However, it is contraindicated in pregnant women, individuals with a history of ACE inhibitor-induced angioedema, and those with severe renal impairment.
Storage and Shelf Life
Store enalapril tablets at room temperature, protected from moisture and excessive heat. Ensure to check the expiry date on the packaging and discard any expired medication. Keep out of reach of children.
Packaging Description
Each package contains 30 tablets of enalapril 5 mg. The tablets are commonly packaged in blister packs or amber glass bottles with child-resistant closures to maintain product integrity and safety.
Clinical Evidence and Proven Effectiveness
Research studies have demonstrated the efficacy of enalapril in reducing blood pressure, improving cardiac function, and reducing the risk of cardiovascular events. Notably, a study published in the New England Journal of Medicine highlighted the significant benefits of enalapril in reducing symptoms and mortality rates in patients with heart failure.
