Ibunorm capsules 200 mg. №10

$6.00

Manufacturer: Ukraine

Traitement symptomatique des maux de tête et des maux de dents, dysménorrhée, névralgie, maux de dos, articulations, muscles, douleurs rhumatismales, ainsi que des symptômes du rhume et de la grippe.

Category:

Description

Ibunorm 200 mg Composition
active substance: ibuprofen;

1 capsule contains ibuprofen 200 mg;

excipients: potato starch, hypromellose, colloidal silicon dioxide, crospovidone, magnesium stearate capsule shell contains titanium dioxide (E 171), gelatin.

Ibunorm 200 mg Dosage form
Capsules.

Basic physical and chemical properties: white hard gelatin capsules. The contents of the capsules are a mixture containing granules and powder from white to off-white. Agglomerates of particles are allowed.

Ibunorm 200 mg Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs. Propionic acid derivatives. ATX code М01А Е01.

Pharmacodynamics
Ibuprofen is an NSAID (NSAID) derivative of propionic acid that has been shown to be effective by inhibiting prostaglandin synthesis. In humans, ibuprofen reduces inflammation pain, swelling, and fever. In addition, ibuprofen reversibly inhibits platelet aggregation.

Experimental data indicate that ibuprofen can competitively suppress the effect of a low dose of acetylsalicylic acid on platelet aggregation with the simultaneous use of these drugs. Some pharmacodynamic studies show that when single doses of ibuprofen 400 mg are used within 8 hours before or within 30 minutes after using immediate release acetylsalicylic acid (81 mg), a decrease in the effect of acetylsalicylic acid on thromboxane formation or platelet aggregation was observed. Although there is uncertainty about the extrapolation of these data to the clinical situation, it cannot be ruled out that regular long-term use of ibuprofen can reduce the cardioprotective effect of low doses of acetylsalicylic acid. With the occasional use of ibuprofen, such a clinically significant effect is considered unlikely.

Ibuprofen relieves pain, reduces inflammation, and lowers fever.

Pharmacokinetics
Ibuprofen is rapidly absorbed after ingestion and is rapidly distributed throughout the body. Excretion is rapid and complete and occurs via the kidneys.

The maximum concentration in blood plasma (Cmax) is reached 45 minutes after ingestion on an empty stomach. When used with food, Cmax is achieved in 1-2 hours. This time may vary for different dosage forms.

The half-life is approximately 2 hours.

In limited studies, ibuprofen has been found in breast milk at very low concentrations.

Indications
Symptomatic treatment of headache and toothache, dysmenorrhea, neuralgia, back pain, joint pain, muscle pain, rheumatic pain, as well as cold and flu symptoms.

Contraindications
Hypersensitivity to ibuprofen or to any of the components of the drug.

History of hypersensitivity reactions (for example, asthma, rhinitis, angioedema or urticaria), which were observed after the use of ibuprofen, acetylsalicylic acid or other NSAIDs.

Peptic ulcer or duodenal ulcer / active bleeding or a history of relapses (two or more severe episodes of confirmed peptic ulcer or bleeding).

A history of gastrointestinal bleeding or perforation associated with taking NSAIDs.

Severe heart failure (NYHA class IV), severe renal failure, or severe liver failure.

The last trimester of pregnancy.

Active inflammatory bowel disease.

Hemorrhagic diathesis or other bleeding disorders.