$9.00
Manufacturer: Ukraine
hypersensitivity to ibuprofen or any component of the drug; a history of hypersensitivity reactions (e.g. BA, rhinitis, Quincke’s edema, urticaria) after ibuprofen, acetylsalicylic acid, or other NSAIDs; stomach or duodenal ulcer/active bleeding or a history of relapses (two or more severe episodes of confirmed peptic ulcer or bleeding); gastrointestinal bleeding or perforation of the gastrointestinal wall in the history associated with the use of NSAIDs; severe heart failure, severe impairment of liver function or severely impaired renal function; i trimester of pregnancy.
Description
Ibuprofen №50 Composition
active substance: ibuprofen;
1 tablet contains ibuprofen 200 mg;
excipients: microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silicon dioxide, corn starch, magnesium stearate.
Ibuprofen №50 Dosage form
Pills.
Basic physical and chemical properties: tablets of white or almost white color, round, with a biconvex surface.
Ibuprofen №50 Pharmacotherapeutic group
Non-steroidal anti-inflammatory and antirheumatic drugs. Propionic acid derivatives. ATX code М01А Е01.
Pharmacodynamics
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid that has been shown to be effective by inhibiting the synthesis of prostaglandins, which mediate pain and inflammation. Ibuprofen has analgesic, antipyretic and anti-inflammatory effects. In addition, ibuprofen reversibly inhibits platelet aggregation.
Experimental evidence suggests that ibuprofen can competitively suppress the effect of low-dose aspirin (acetylsalicylic acid) on platelet aggregation when these drugs are used concomitantly. Some pharmacodynamic studies show that when using single doses of ibuprofen 400 mg within 8 hours before or within 30 minutes after using aspirin (acetylsalicylic acid) immediate release (81 mg), there was a decrease in the effect of aspirin (acetylsalicylic acid) on thromboxane formation or platelet aggregation … Although there is uncertainty about the extrapolation of these data to the clinical situation, it cannot be ruled out that regular long-term use of ibuprofen may reduce the cardioprotective effect of low doses of acetylsalicylic acid. With the occasional use of ibuprofen, such a clinically significant effect is unlikely.
Ibuprofen relieves pain, reduces inflammation, and lowers fever.
Pharmacokinetics
Ibuprofen is rapidly absorbed in the gastrointestinal tract and binds to plasma proteins.
The maximum concentration in serum is determined 45 minutes after taking on an empty stomach. When this drug is taken with food, peak levels are observed 1 to 2 hours after use. Ibuprofen is metabolized in the liver, excreted by the kidneys unchanged or in the form of metabolites. The half-life is almost 2 hours. In elderly patients, there are no significant differences in the pharmacokinetic profile.
Indications
Symptomatic treatment of headache, toothache, dysmenorrhea, neuralgia, back pain, joint pain, muscle pain, rheumatic pain, as well as treatment of cold and flu symptoms.
Contraindications
Hypersensitivity to ibuprofen or to any of the components of the drug;
a history of hypersensitivity reactions (such as asthma, rhinitis, angioedema, or urticaria) after using ibuprofen, acetylsalicylic acid (aspirin), or other NSAIDs;
peptic ulcer and duodenal ulcer / active bleeding or a history of relapses (two or more severe episodes of confirmed peptic ulcer or bleeding);
a history of gastrointestinal bleeding or perforation of the wall of the gastrointestinal tract associated with the use of NSAIDs;
severe heart failure (NYHA class IV), severe renal failure, or severe liver failure;
active inflammatory bowel disease;
hemorrhagic diathesis or other bleeding disorders;
the last trimester of pregnancy.
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