Ilomedin concentrate for infusions 20 mcg/ml. 1ml. №5

Description

Ilomedin Composition
active substance: iloprost;

1 ml of solution is 0.027 mg iloprost trometamol, of which 20 μg iloprost corresponds;

excipients: trometamol, ethanol 96%, sodium chloride, diluted hydrochloric acid, water for injection.

Ilomedin Dosage form
Concentrate for preparation of solution for infusion.

Basic physical and chemical properties: transparent liquid, free of particles.

Ilomedin Pharmacotherapeutic group
Antiplatelet agents.

ATX code B01A C11.

Pharmacodynamics
Iloprost is a synthetic analogue of prostacyclin, the pharmacological action of which is:

inhibition of aggregation, adhesion and platelet release reaction;
dilatation of arterioles and venules;
an increase in capillary density and a decrease in increased vascular penetration into microcirculation systems
activation of endogenous fibrinolysis;
Treatment of leukocyte adhesion after leukocyte removal and leukocyte accumulation in damaged tissue, as well as reducing the release of free oxygen radicals.
The exact mechanism of action is not known.

Pharmacokinetics
Distribution

The station of the administered dose and the metabolic assessment of iloprost (increased concentration) are reached 10-20 hours after the administration of the internal infusion. The equilibrium concentration in blood plasma linearly depends on the dose of the administered drug per unit of time. At a dosage of 3 ng / kg / min, the concentration is reached, approximately at 135 ± 24 pg / ml. After the end of the infusion, the concentration of iloprost in the blood plasma decreases very rapidly (this is due to the high intensity and metabolism). The metabolic clearance of the active substance from blood plasma is approximately 20 ± 5 ml / kg / min. Redirection of plasma blood circulation to the thermostatic phase of formation of 0.5 years, inherited 2 years after treatment in preparations for setting less than 10% production concentration.

The pharmacokinetics of iloprost does NOT contribute to the elimination of deficiencies in the body and statics of the patient, while the quality of drugs improves within 2-4 times over a long period of treatment with drugs, drugs and drugs. Unlike their drugs on plasmin proteins, it is unlikely, since most of iloprost is associated with albumin of plasma blood circulation (concentration and specificity from new from from from from from from from from from from from from from by from through from from from from from from from from from from from life to from absolute from the absolute probability of influence of other drugs on the basis of an extremely low probability of influence of other drugs on the pathway of the drug is 60% and the same way, by

Indications
Progressive thromboangiitis obliterans (Buerger’s disease) in severe perfusion disorders in the absence of indications for revascularization.

Contraindications
Hypersensitivity to the active substance or to any other component of the drug.