$4.50
Manufacturer: Ukraine
Rectal suppositories.
Description
Indometacin Plus Composition
active ingredients: indomethacin, dimethyl sulfoxide;
1 g of ointment contains 50 mg of indomethacin, 50 mg of dimethyl sulfoxide;
excipients: peppermint oil, propylene glycol, polyethylene glycol 400, polyethylene glycol 1500.
Indometacin Plus Dosage form.
Ointment.
Basic physical and chemical properties: greenish-yellow ointment with a weak specific odor.
Pharmacotherapeutic group. Topical non-steroidal anti-inflammatory drugs. ATX code M02A A.
Indometacin Plus Pharmacological properties
Pharmacodynamics.
Anti-inflammatory, analgesic, antiaggregatory agent. Blocks the enzyme cyclooxygenase (COX), which is involved in the conversion of arachidonic acid, resulting in impaired synthesis of prostaglandins, which play an important role in the development of inflammatory reactions, fever, pain. Inhibits the activity of inflammatory mediators, hyaluronidase, lysosomal hydrolases.
Indomethacin causes weakening or disappearance of pain syndrome of a rheumatic and non-rheumatic nature.
Dimethyl sulfoxide, penetrating through biological membranes, including skin, enhances the penetration of indomethacin through intact skin.
Pharmacokinetics.
When applied to the skin, indomethacin is partially absorbed into the systemic circulation. The time to reach the maximum concentration in the blood is approximately 2 hours. Indomethacin penetrates well into tissues. Biotransformed in the liver with the formation of inactive metabolites of indomethacin and its conjugates with glucuronic acid. Unchanged indomethacin and inactive metabolites are excreted by the kidneys and bile.
Clinical characteristics.
Indications
An additional agent in the complex treatment of acute and chronic rheumatoid arthritis, osteoarthritis, osteoarthritis, ankylosing spondylitis, psoriatic polyarthritis, gouty arthritis;
localized forms of extra-articular rheumatism of the musculoskeletal system: tendinitis, synovitis, tendovaginitis, inflammation of the fascia and articular ligaments, bursitis;
local symptomatic treatment of inflammation, pain and edema in post-traumatic lesions of the musculoskeletal system – sprains, dislocations, bruises.
Contraindications
Hypersensitivity to the components of the drug. Hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) with clinical manifestations of an asthmatic attack, urticaria, or allergic rhinitis. Peptic ulcer and duodenal ulcer, ulcerative colitis, bronchial asthma, rhinitis, conjunctivitis or bronchospasm while taking NSAIDs, hemophilia, hypocoagulation, glucose-6-phosphate dehydrogenase deficiency, blood diseases.
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