Indometacin Sofarma ointment 10% 40 g. tube

$5.00

Manufacturer: Bulgaria

Rectal suppositories.

Category:

Description

Indometacin Sofarma Composition
active substance: indomethacin;

1 g of ointment contains 0.1 g of indomethacin;

excipients: lavender oil, lanolin, white soft paraffin, dimethyl sulfoxide, yellow wax, anhydrous colloidal silicon dioxide.

Indometacin Sofarma Dosage form.

Ointment.

Basic physical and chemical properties: homogeneous yellow ointment with a specific odor

Indometacin Sofarma Pharmacotherapeutic group.

Topical non-steroidal anti-inflammatory drugs. Indomethacin.

ATX code М02А A23.

Pharmacological properties

Pharmacodynamics.

Indomethacin is an indoleacetic acid derivative belonging to the group of non-steroidal anti-inflammatory drugs. Indomethacin has a powerful inhibitory effect on prostaglandin synthesis by suppressing the enzyme cyclooxygenase, which plays a significant role in reducing inflammation, pain and hyperthermia. It has antipyretic properties and reversibly inhibits platelet aggregation. When applied topically, indomethacin has a direct anti-inflammatory and analgesic effect on inflamed tissues.

Pharmacokinetics.

The ointment is well resorbed through the skin and accumulates in subcutaneous tissues at therapeutic concentrations, including joints and synovial fluid. It is excreted by the kidneys in the form of metabolites and in small quantities – unchanged, including when applied topically; in small amounts it is excreted through the biliary tract into the intestines.

Clinical characteristics.

Indications

An additional agent in the complex therapy of acute and chronic rheumatoid arthritis, osteoarthritis, osteoarthritis, ankylosing spondylitis, psoriatic polyarthritis, gouty arthritis;
localized forms of extra-articular rheumatism of the musculoskeletal system: tendinitis, synovitis, tendovaginitis, inflammation of the fascia and articular ligaments, bursitis;
local symptomatic treatment of inflammation, pain and edema in post-traumatic lesions of the musculoskeletal system – sprains, dislocations, bruises.

Contraindications

Hypersensitivity to the active or any of the excipients of the drug. Hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) with clinical manifestations of an asthmatic attack, urticaria, or allergic rhinitis.