Description

Intagra ІS Coated Tablets 0.025 g. №4

Ingredients

Intagra ІS tablets contain 0.025 g of the active ingredient sildenafil citrate. The tablets also include excipients such as microcrystalline cellulose, croscarmellose sodium, and magnesium stearate.

Dosage

Intagra ІS tablets should be taken orally as directed by a healthcare provider. The usual recommended dose is 50 mg taken as needed, approximately 1 hour before sexual activity. The maximum recommended dosing frequency is once per day.

Indications

Intagra ІS tablets are indicated for the treatment of erectile dysfunction in adult men. It works by increasing blood flow to the penis during sexual stimulation, helping to achieve and maintain an erection.

Contraindications

Intagra ІS tablets are contraindicated in individuals with a known hypersensitivity to sildenafil or any other component of the tablet. It should not be used in patients taking nitrates for chest pain or guanylate cyclase stimulators for pulmonary hypertension.

Directions

Intagra ІS tablets should be swallowed whole with a glass of water. They can be taken with or without food. Avoid consuming grapefruit or grapefruit juice while taking this medication as it may increase the risk of side effects.

Scientific Evidence

Studies have shown the efficacy of sildenafil, the active ingredient in Intagra ІS tablets, in treating erectile dysfunction. A meta-analysis published in the Journal of Sexual Medicine concluded that sildenafil is a safe and effective treatment for erectile dysfunction, with a significant improvement in erectile function compared to placebo.

Additional Information

It is important to note that Intagra ІS tablets do not protect against sexually transmitted diseases. Patients with underlying cardiovascular conditions should consult their healthcare provider before using this medication. If an erection lasts longer than 4 hours, seek immediate medical attention to prevent long-term injury.

Intagra ІS tablets act by inhibiting the enzyme phosphodiesterase type 5 (PDE5), leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. This results in smooth muscle relaxation and vasodilation, enhancing blood flow to the penis during sexual stimulation and facilitating an erection.

Compared to similar drugs in its class, Intagra ІS tablets have demonstrated comparable efficacy in the treatment of erectile dysfunction with a similar safety profile. Clinical trials have shown that sildenafil is well-tolerated and effective in improving erectile function across various etiologies of erectile dysfunction.