Itomed coated tablets 50 mg. №40

Description

Itomed №40 Composition
active substance: itopride hydrochloride;

1 tablet contains 50 mg of itopride hydrochloride;

excipients: lactose monohydrate, corn starch; croscarmellose sodium; silicon dioxide colloidal magnesium stearate Opadry II White 85F 18422 (titanium dioxide (E 171), polyvinyl alcohol, talc, polyethylene glycol).

Itomed №40 Dosage form
Film-coated tablets.

Basic physical and chemical properties: white or almost white tablets, film-coated, biconvex, with a notch on one side, with a diameter of about 7 mm.

Itomed №40 Pharmacotherapeutic group
Means used for functional disorders of the digestive tract. Peristalsis stimulants. ATX code A03F A.

Pharmacodynamics
Itopride hydrochloride activates propulsive motility of the gastrointestinal tract due to antagonism with dopamine D2 receptors and inhibitory activity of acetylcholinesterase. Itopride hydrochloride activates the release of acetylcholine and inhibits its breakdown.

Itopride hydrochloride also has an antiemetic effect due to interaction with D2 receptors localized in the chemoreceptor trigger zone, which was demonstrated by dose-dependent inhibition of apomorphine-induced vomiting in animals.

The action of itopride hydrochloride is highly specific for the upper gastrointestinal tract.

Itopride hydrochloride does not affect serum gastrin levels.

Itoprid hydrochloride accelerates the evacuation of gastric contents, improves gastroduodenal coordination, and stimulates the passage of intestinal contents.

Indications
Relief of gastrointestinal symptoms of functional non-ulcer dyspepsia (chronic gastritis), namely:

bloating;
a feeling of rapid oversaturation;
pain and discomfort in the upper abdomen;
heartburn;
nausea;
vomit;
anorexia.

Contraindications
Hypersensitivity to the active substance or to any component of the drug.

Conditions in which an increase in the contractile activity of the gastrointestinal tract can be harmful, such as gastrointestinal bleeding, mechanical obstruction or perforation.

Application features
Itopride hydrochloride enhances the action of acetylcholine and may exhibit cholinergic side reactions. Long-term data are not available.

Elderly people, given the decrease in liver and kidney function in them and concomitant diseases or concomitant therapy with other drugs, should be careful when using itoprid due to the possible frequent development of adverse reactions.

If a dose is missed, it must be taken as soon as possible; do not use if it is time to take the next dose DO NOT double the dose.

The drug contains lactose, therefore, patients with rare hereditary forms of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.