$12.00
Manufacturer: Germany
hypothyroidism; euthyroid goiter; as replacement therapy and to prevent recurrence of goiter after resection of the thyroid gland; thyroid cancer (after surgical treatment); diffuse toxic goiter: after reaching the euthyroid state by thyrostatics (in the form of combined or monotherapy); as a diagnostic tool for the thyroid suppression test.
Description
L-Tiroxine 100 mcg Composition
active substance: levothyroxine sodium;
1 tablet contains levothyroxine 100 mcg;
excipients: calcium hydrogen phosphate dihydrate, microcrystalline cellulose, dextrin, sodium starch (type A), long-chain partial glycerides.
L-Tiroxine 100 mcg Dosage form
Pills.
Round, slightly convex tablets from white to slightly beige, with a notch for division on one side and embossed “100” on the other.
The tablet can be divided into equal parts.
L-Tiroxine 100 mcg Pharmacotherapeutic group
Thyroid therapy, thyroid hormones. ATX code Н03А А01.
L-Tiroxine 100 mcg Pharmacodynamics
Mechanism of action.
Synthetic levothyroxine, which is found in the preparations L-thyroxin 50 Berlin-Chemie and L-thyroxin 100 Berlin-Chemie, is identical in action to the natural thyroid hormone produced mainly by the thyroid gland. There is no disagreement between endogenously formed and exogenous levothyroxine for the body.
Pharmacodynamic effects.
After partial conversion to liothyronine (T3), mainly in the liver and kidneys, and the transition to the cells of the body, the characteristic effects of thyroid hormones are observed on the development, growth and metabolism through the activation of T3 receptors.
Clinical efficacy and safety.
Substitution of thyroid hormones leads to the normalization of metabolic processes. For example, taking levothyroxine leads to a significant reduction in high cholesterol levels associated with hypothyroidism.
Pharmacokinetics
Suction.
The absorption of orally taken levothyroxine occurs mainly in the upper part of the small intestine, the degree of absorption of which depends mainly on the galenic form of the drug and can be up to 80% when taken on an empty stomach. If the drug is taken with food, its absorption is significantly reduced.
The maximum concentration in blood plasma is reached 2-3 hours after ingestion.
The effect of the drug is observed 3-5 days after the start of oral therapy.
Distribution.
The volume of distribution is approximately 10-12 liters. Levothyroxine binds to specific plasma proteins by about 99.97%. The binding of proteins to hormones is not covalent, thus there is a constant and very rapid exchange between free and bound hormone.
Output.
The metabolic clearance for levothyroxine is approximately 1.2 liters of plasma per day. Cleavage occurs mainly in the liver, kidneys, brain, and muscles. Metabolites are excreted in urine and feces. The half-life is about 7 days with hyperthyroidism, this period is reduced (up to 3-4 days), and with hypothyroidism, it increases (up to about 9-10 days).
Pregnancy and breastfeeding.
Levothyroxine crosses the placenta only in small amounts. In the case of taking the drug in usual doses, levothyroxine is excreted into breast milk only in small amounts.
Impaired renal function.
Due to the high level of protein binding, neither hemodialysis nor hemoperfusion affects the level of levothyroxine.
Indications
benign goiter with euthyroid state of thyroid function;
prevention of recurrence of goiter after resection of goiter with euthyroid state of thyroid function;
replacement therapy for hypothyroidism of various etiologies
adjuvant for thyreostatic therapy of hyperthyroidism after reaching the euthyroid functional state;
suppressive and replacement therapy for thyroid cancer, mainly after thyroidectomy.
as a diagnostic tool for the thyroid suppression test.
Contraindications
Hypersensitivity to the active substance or to any of the excipients of the drug.
Untreated hyperthyroidism of any origin.
Untreated adrenal insufficiency.
Untreated pituitary insufficiency (this leads to insufficiency of the adrenal cortex, requires treatment).
Acute myocardial infarction.
Acute myocarditis.
Acute pancarditis.
During pregnancy, the simultaneous use of levothyroxine and any thyreostatic agent is contraindicated (for more information on use during pregnancy and lactation, see the section “Use during pregnancy or lactation”).
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