Laen coated tablets 600 mg. №10

Description

Laen Composition
active substance: linezolid (linezolid);

1 tablet contains linezolid 600 mg;

excipients: microcrystalline cellulose, partially corn starch, sodium starch (type A), hydroxypropyl cellulose, magnesium stearate, Opadry 03B58600 coating white: hypromellose, titanium dioxide (E 171), polyethylene glycol.

Laen Dosage form
Film-coated tablets.

Basic physical and chemical properties: oval, biconvex tablets, smooth on both sides, film-coated white.

Laen Pharmacotherapeutic group
Antibacterial agents for systemic use. ATX code J01X X08.

Laen Pharmacodynamics
General characteristics.

Linezolid is a synthetic antibacterial agent that belongs to a new class of antimicrobial drugs – oxazolidinones.

It is active in vitro against aerobic gram-positive bacteria and anaerobic microorganisms.

Linezolid selectively inhibits protein synthesis in bacterial cells through a unique mechanism of action. In particular, it binds to a site on the bacterial ribosome (23S subunit with 50S) and prevents the formation of a functional 70S initiation complex, which is an important component of the translation process.

Indications
Treatment of infections caused by susceptible strains of certain microorganisms, in the following conditions:

nosocomial pneumonia;
community-acquired pneumonia;
complicated infections of the skin and its structures, in particular infections against the background of a diabetic foot without concomitant osteomyelitis, caused by Staphylococcus aureus (methicillin-susceptible and methicillin isolates), Streptococcus pyogenes or Streptococcus agalactiae; Linezolid has not been studied in the treatment of ulcerative pressure ulcers;
uncomplicated infections of the skin and its structures caused by Staphylococcus aureus (only methicillin-sensitive isolates) or Streptococcus pyogenes;
vancomycin-resistant infections caused by Enterococcus faecium, including infections accompanied by bacteremia.
Linezolid is not indicated for the treatment of gram-negative infections. In case of suspicion or detection of a gram-negative pathogen, specific gram-negative therapy should be started immediately.

Contraindications
Hypersensitivity to linezolid or to any other component of the drug.

Simultaneous administration of any drugs that inhibit monoamine oxidase A and B (such as phenelzine, isocarboxazid, selegiline, moclobemide), or within two weeks after taking such drugs.

Except in cases where there is a possibility of careful observation and monitoring of blood pressure, Laen should not be prescribed to patients with such concomitant clinical conditions or concomitant use of the following drugs:

uncontrolled arterial hypertension, pheochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizoaffective disorder, acute episodes of dizziness;
selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, 5-HT 1 serotonin receptor agonists (triptans), direct and indirect sympathomimetics (including adrenergic receptor bronchodilators, pseudoephedrine, phenylpropanolamine), dopinephenergamines, norepinephrine amines (dopinephrine amines) ), pethidine or buspirone.