Lamizil spray 1% 30 ml.

Description

Lamizil spray Composition
active substance: terbinafine hydrochloride;

1 g of spray contains 10 mg of terbinafine hydrochloride, which corresponds to 8.8 mg of terbinafine;

auxiliary substances: purified water, ethanol (96%), propylene glycol, propylene glycol, cetostearyl ether.

Lamizil spray Dosage form
Spray for skin 1%.

Transparent colorless or yellowish liquid.

Lamizil spray Pharmacotherapeutic group
Antifungal drugs for topical use. ATC code D01A E15.

Pharmacodynamics
Terbinafine is an allylamine with a broad spectrum of antifungal activity. Terbinafine in an appropriate concentration has a fungicidal effect against dermatophytes, molds and some dimorphic fungi. Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic.

Terbinafine specifically inhibits the early stage of sterol biosynthesis in the fungal cell membrane. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which causes the death of the fungal cell. Terbinafine works by inhibiting the enzyme squalene epoxidase in the cell membrane of the fungus. This enzyme does not belong to the cytochrome P450 system. Terbinafine does not affect the metabolism of hormones or other drugs.

Pharmacokinetics
When applied topically, the drug is almost not absorbed, quickly begins to act, reveals effectiveness with short-term treatment (7 days).

When applied externally, less than 5% of the dose is absorbed, therefore the systemic exposure of terbinafine is very low.

Indications
Fungal skin infections caused by dermatophytes such as Trichophyton (eg T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum, eg athlete’s foot (athlete’s foot), groin dermatophytosis ( “Jockey’s itch”), dermatophytosis of the trunk (“ringworm”). Versicolor versicolor caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Lamizil spray Contraindications
Hypersensitivity to terbinafine or any component of the drug.

Interaction with other medicinal products and other types of interactions
Unknown.

The ability to influence the reaction rate when driving or operating machinery
Does not affect.