$139.00
Manufacturer: UK
Fungal skin infections caused by dermatophytes such as Trichophyton (e.g. T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis, and Epidermophyton floccosum, such as foot dermatophytosis; inguinal dermatophytosis (“jockey’s itch”); torso dermatophytosis (ringworm); skin candidiasis caused by fungi of the genus Candida, usually Candida albicans; a multicolored lichen (pityriasis versicolor) caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Description
Lamizil tablets Storage
active substance: terbinafine;
1 tablet contains terbinafine hydrochloride 281.25 mg, which in terms of terbinafine is equal to 250 mg;
Excipients: magnesium stearate, colloidal anhydrous silica, hypromellose, sodium starch glycolate (type A), microcrystalline cellulose.
Lamizil tablets Dosage form
Tablets.
Basic physical and chemical properties
tablets are round, biconvex, with beveled edges, white to white with a yellow tinge, with a smooth or slightly uneven surface, with a line on one side and the inscription LAMISIL 250 (in a circle) on the other side of the tablet.
Lamizil tablets Pharmacotherapeutic group
Antifungal drugs for use in dermatology. Antifungal drugs for systemic use. Terbinafine.
ATX code D01B A02.
Lamizil tablets Pharmacological properties
Pharmacodynamics
Terbinafine is an allylamine that has a broad spectrum of antifungal activity against skin, hair and nail infections caused by dermatophytes such as Trichophyton (eg T. rubrum, T. mentagrophytes, T. verrucosum, T. tonsurans, T. violaceum), Microsporum (eg Microsporum canis), Epidermophyton floccosum and yeast fungi of the genus Candida (eg Candida albicans) and Pityrosporum. At low concentrations, terbinafine has a fungicidal effect against dermatophytes, molds and some dimorphic fungi. The activity against yeast fungi can be fungicidal or fungistatic, depending on their species.
Terbinafine specifically promotes the early stage of sterol biosynthesis in the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes fungal cell death. This enzyme does not belong to the cytochrome P450 system.
When used orally, the drug accumulates in the skin in concentrations that provide a fungicidal effect of the drug.
Indication
Fungal infections of the skin and nails caused by Trichophyton (eg T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum:
Ringworm (trichophytia of smooth skin, trichophytia of the perineum and dermatophytia of the feet), when the location of the lesion, the severity or prevalence of the infection determine the appropriateness of oral therapy.
Onychomycosis.
Contraindication
Acute or chronic liver disease.
Hypersensitivity to terbinafine or to any of the excipients.
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