Liv.52 (capparis spinosa, wild chicory) tablets №100

Description

Liv.52 composition
active substances: 1 tablet contains powders: roots of Capparis spinosa – 65 mg; wild chicory seeds (Cichorium intybus) – 65 mg; black nightshade (Solanum nigrum) – 32 mg; Cassia occidentalis – 16 mg; bark of Terminal arjuna (Terminalia arjuna) – 32 mg; Tamarix gallica – 16 mg; yarrow seeds (Achillea millefolium) – 16 mg; iron oxide (Mandur bhasma) – 33 mg; which are treated with an aqueous extract of: eclipses of white (Eclipta alba), bitter phyllanthus (Phyllanthus amarus), roots of Berhavia diffusa (Boerhaavia diffusa), stems of Tinospora cordifolia, roots of radish Embusicus sowing radish ), rhizomes of Ceylon lead (Plumbago zeylanica), currant seeds (Embelia ribes), mirabolan tree fruit (Terminalia chebula), fumaria officinalis;

Excipients: magnesium stearate, microcrystalline cellulose, croscarmellose sodium, sodium carboxymethylcellulose, colloidal anhydrous silica.

Dosage form
Tablets.

Pharmacological properties
Combined herbal hepatoprotective agent. Protects the liver parenchyma from toxic agents. The hepatoprotective effect of the drug is due to the antioxidant and membrane-stabilizing properties of its components. The drug increases the level of endogenous tocopherols in hepatocytes and the level of cytochrome P450. Liv.52 stimulates the biosynthesis of proteins and phospholipids. Promotes the reconstruction of hepatocytes, reduces degenerative, fatty and fibrous changes, enhances intracellular metabolism.
The drug regulates the level of plasma proteins in the blood, normalizes the albumin / globulin ratio. Provides normalization of plasma transaminases, cholesterol, triglycerides, reducing the manifestations of dyslipidemia. Reduces bilirubin and alkaline phosphatase. Increases the liver’s ability to store glycogen.
Improves the colloidal properties of bile, prevents the formation of gallstones. Improves the contractile function of the gallbladder. Improves the processes of digestion and assimilation of food. Stimulates hematopoiesis.
In alcoholic liver disease, the drug reduces the level of ethanol in the blood and urine; increases the activity of acetaldehyde dehydrogenase, which helps to reduce the level of acetaldehyde; prevents the binding of acetaldehyde to cell proteins, accelerates its excretion.

Indication
Comprehensive treatment and prevention of chronic diffuse liver disease, alcoholic liver disease, radioactive and chemotherapeutic liver disease. As a means to increase the body’s resistance to hepatotoxic lesions, to accelerate recovery during convalescence after severe illness, surgery. Cholecystoangiocholitis and biliary dyskinesia.

Contraindication
Hypersensitivity to the components of the drug and to other plants of the family Asteraceae (Compositae). Gallstone disease. Acute inflammatory diseases of the stomach and intestines. Increased blood clotting, propensity to thrombosis.
Interaction with other medicinal products and other forms of interaction
Concomitant use of Liv.52 and ibuprofen decreases the level of the latter in the body due to delayed absorption. When used concomitantly with tetracycline or doxycycline reduces the bioavailability of antibiotics.

Features of application
There are reports of the development of epidermal necrolysis in patients with chronic and acute infectious hepatitis who took Liv.52.
In acute infectious hepatitis, the drug is used on prescription with caution.

Children
Efficacy and safety of the drug in children under 6 years has not been established, so it is contraindicated to prescribe it to this age group of patients.

Use during pregnancy or breastfeeding
Contraindicated.

Method of application and dosage
Liv.52 tablets are taken orally.

• Adults and children over 14 years of age are prescribed 2 tablets 3 times a day.
• Children aged 6 to 14 years are prescribed 1 tablet 3 times a day.

The course of treatment is determined by the doctor depending on the nature and course of the disease.
With alcoholic liver disease, adults are prescribed 2 tablets 3 times a day for 1 month, then 1 tablet 3 times a day for 6 to 12 months.

Overdose
No cases of overdose were observed. Dizziness or increased side effects may occur. There is no specific antidote. Treatment is symptomatic.

Side effects:

• From the skin and subcutaneous tissue: redness, rash, itching, skin swelling, severe skin reactions, including toxic epidermal necrolysis.
• From the digestive tract: dyspeptic symptoms, nausea, weakening of bowel movements.

Hypersensitivity reactions are possible with the use of the drug.

Expiration date
3 years.

Storage conditions
Store at a temperature not exceeding 30 ° C in the original package.
Keep out of reach of children.