Lomustine Medak capsules 40 mg. №20

Description

Lomustine Medak composition
active substance: lomustine;
1 capsule contains lomustine 40 mg;
Excipients: lactose monohydrate, wheat starch, talc, magnesium stearate, gelatin, titanium dioxide (E 171), indigo carmine (E 132).

Dosage form
Capsules.

Pharmacological properties
Lomustine Medak is an alkylating drug from the group of nitrosourea. Lomustine and / or its metabolites disrupt the function of DNA, RNA and inhibit DNA synthesis.
Lomustine Medak acts as an alkylating agent, as an inhibitor of several stages of nucleic acid synthesis, and as an inhibitor of the repair of single-stranded DNA breaks.

Indication
Palliative therapy, as an adjunct to other treatments, or in standard regimens of combination therapy with other known chemotherapeutic drugs in the following conditions:

• brain tumors (primary and metastatic);
• lung tumors (especially small cell carcinoma);
• Hodgkin’s disease (resistant to traditional chemotherapy);
• malignant melanoma (with metastases).

Also as a second-line treatment for non-Hodgkin’s lymphoma.

Contraindication:

• hypersensitivity to nitrourea drugs;
• insensitivity of the tumor to nitrosourea drugs;
• severe bone marrow depression;
• severe renal failure;
• celiac disease or wheat allergy;
• concomitant use of the yellow fever vaccine or other live vaccines in immunocompromised patients.

Children
Lomustine treatment of cancer patients (except for brain tumors) should be carried out only in specialized centers and in exceptional situations. The dose for children, as well as for adults, depends on the body surface area (120-130 mg / m2 every 6-8 weeks) and is adjusted according to the same criteria.

Pregnancy and breastfeeding period
Before using the drug, it is imperative that you go to the doctor and turn your attention to the composition of this drug. If its ingredients do not harm the health of your baby and your health, then you can use the medication.

Mode of application
In order to exclude the appearance of side reactions of the body to the drug, your attending specialist, after consultation and diagnosis, prescribes the dosage according to which you should use this drug.
Doctors advise using the drug for treatment in exactly this dosage: it is applied orally at a dose of 120-130 mg / sq. meter every 6-8 weeks, but it is recommended to distribute the dose of the drug at 40 mg / sq. meter over 3 days.
The duration of use depends on the effectiveness of the drug on the patient’s body.

Overdose
Patients inadvertently used this drug to a greater extent than recommended by the attending physician and, at the same time, they had the following symptoms of the body’s response to the drug: increased side effects, death, difficulty breathing, myelotoxicity, dizziness, lethargy.

Adverse reactions
Situations with patients who had adverse reactions were recorded and at the same time the following symptoms were observed: nausea, leukopenia, increased alkaline phosphatase in the blood, pulmonary fibrosis, acute leukemia, stomatitis, renal failure, vomiting, thrombocytopenia, alopecia, myelodysplastic syndrome, azotemia, lung infiltration, anemia.

Storage conditions
It is recommended to store this medicine in a place that is dark, preferably very dry, to which children under the age of 18 do not have access, and the temperature of this place, without fail, should not exceed +25 ° C.
The shelf life of the medicine lasts 36 months from the date of manufacture, which is indicated on each package of the medicine.