Memoplant (Ginkgo biloba) coated tablets 40 mg. №20

Description

Memoplant composiion
active substance: dry extract (EGb 761®) from the leaves of ginkgo biloba (Ginkgo biloba) (35-67: 1), standardized to 8.8-10.8 mg of flavonoid glycosides of ginkgo and up to 2.0-2.8 mg of terpenlactone , of which 1.12-1.36 mg – ginkgolides A, B and C and 1.04-1.28 mg – bilobalide, and not more than 0.2 μg of ginkgolic acids, extractant: acetone 60% (m / m) ;
1 film-coated tablet contains 40 mg of dry extract (EGb 761®) of Ginkgo biloba leaves (35-67: 1), standardized to 8.8-10.8 mg of flavonoid glycosides of ginkgo and up to 2.0 -2.8 mg of terpenlactones, of which 1.12-1.36 mg – ginkgolides A, B and C and 1.04-1.28 mg – bilobalide, and not more than 0.2 μg of ginkgolic acids, extractant: acetone 60 % (w / w);
Excipients: croscarmellose sodium, antifoam agent SE 2, colloidal anhydrous silica, hypromellose, lactose monohydrate, macrogol 1500, magnesium stearate, corn starch, microcrystalline cellulose, talc, titanium dioxide (E 171) iron hydroxide yellow (E 172).

Dosage form
Coated tablets.

Pharmacological properties
The drug is of plant origin, normalizes metabolism in cells, rheological properties of blood and microcirculation. Improves cerebral circulation and the supply of oxygen and glucose to the brain, prevents erythrocyte aggregation, inhibits platelet activating factor. Has a dose-dependent regulatory effect on the vascular system, stimulates the production of endothelium-dependent laxative factor (nitric oxide – NO), dilates small arteries, increases venous tone, thereby regulating blood supply to blood vessels. Reduces the permeability of the vascular wall (anti-edematous effect both at the level of the brain and at the periphery). Has an antithrombotic effect (due to the stabilization of platelet and erythrocyte membranes, the impact on the synthesis of prostaglandins, reducing the action of biologically active substances and platelet-activating factor). Prevents the formation of free radicals and lipid peroxidation of cell membranes. Normalizes the release, reuptake and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to bind to receptors. Has an antihypoxic effect, improves metabolism in organs and tissues, promotes the accumulation of macroergs in cells, increases the utilization of oxygen and glucose, normalization of mediator processes in the central nervous system.

Indications
Memoplant is used in the treatment of functional and organic disorders of the brain resulting from stroke, traumatic brain injury and age-related changes caused by cerebral atherosclerosis, conditions after brain surgery, Alzheimer’s disease and dementia.
The drug has proven to be effective in the treatment of peripheral circulation disorders, such as diabetic angiopathy, obliterating atherosclerosis of the vessels of the lower extremities, Reino’s disease, endarteritis.
It is used in the treatment of disorders of the vestibular apparatus, such as dizziness, gait disturbances, tinnitus.
In addition, Memoplant can be taken by students in preparation for the session or in conditions of increased academic loads.

Contraindications
The pre-drug is not prescribed in the acute period of cerebrovascular accident, in the acute period of myocardial infarction, with reduced blood clotting, erosive ulcerative gastritis and gastric ulcer. The drug is not used in the therapy of patients under 12 years of age, patients suffering from hypersensitivity to the components of the drug, nursing and pregnant women.
Due to the fact that the drug contains lactose, its appointment is unacceptable to patients with a hereditary form of galactosemia, galactose malabsorption syndrome or congenital lactase deficiency.

Application during pregnancy and lactation
For pregnant and lactating women, the drug is not prescribed, since there is no reliable information regarding its effect on the development of the fetus and newborn.

Method of administration and dosage
When treating organic disorders in the brain, Memoplant is consumed 3 to 4 times a day, or twice a day.

The tablets are taken regardless of meals, without chewing and drinking a little water. Duration of treatment is from 6 to 8 weeks. After three months of treatment, the feasibility of further therapy is assessed. If clinically significant symptoms of the disease persisted after taking the drug for 6 or 8 weeks, the treatment was stopped due to its low efficacy.

Overdose
So far, no cases of overdose with Memoplant have been officially registered. If you suspect that the patient has taken the drug in an increased dosage, then he urgently needs to rinse the stomach, ensure the intake of activated charcoal and prescribe the correct symptomatic treatment.

Side effects
Treatment with Memoplant is well tolerated by patients, but in some patients, taking the drug may be accompanied by the development of allergic reactions, dyspeptic disorders, headaches and increased dizziness.

Storage conditions and periods
Memoplant should be stored in a dark and protected from moisture place, out of reach of children. The shelf life of the drug is 5 years.