Description

Metotrexat Solution for Injections 10 mg/ml. 5 ml. Vial №1

Ingredients

Active ingredient: Methotrexate. Inactive ingredients may include sodium chloride, sodium hydroxide, and water for injections.

Dosage

Dosage: The usual adult dosage for methotrexate in the treatment of rheumatoid arthritis ranges from 7.5 to 20 mg once weekly. Dosage may vary based on the condition being treated.

Indications

Indications: Methotrexate is indicated for the treatment of various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer.

Contraindications

Contraindications: Do not use methotrexate if you are pregnant, breastfeeding, or have liver disease. It is contraindicated in patients with preexisting blood disorders.

Directions

Directions: Methotrexate is administered by injection under the supervision of a healthcare professional. Follow all instructions provided by your doctor.

Scientific Evidence

Methotrexate has been extensively studied for its efficacy in the treatment of rheumatoid arthritis. Research published in the Journal of Rheumatology has shown that methotrexate is effective in reducing disease activity and joint damage in patients with rheumatoid arthritis.

Additional Information

It is important to monitor for potential side effects such as liver toxicity and bone marrow suppression while using methotrexate. Regular blood tests are usually recommended to monitor for these adverse effects.

Pharmacological Effects

Methotrexate works by inhibiting dihydrofolate reductase, an enzyme involved in the synthesis of DNA, RNA, and proteins. This action leads to the suppression of immune responses and the proliferation of certain cells, making it effective in the treatment of autoimmune diseases and cancer.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of methotrexate in the management of rheumatoid arthritis, psoriasis, and certain types of cancer. Compared to other disease-modifying antirheumatic drugs (DMARDs), methotrexate has shown comparable effectiveness with a favorable safety profile.

Overall, methotrexate solution for injections is a well-established medication with proven efficacy in various conditions. Consult with your healthcare provider for personalized treatment recommendations based on your specific medical needs.