Migranol (sumatriptan) coated tablets 50 mg. №10

Description

Migranol composition
active substance: sumatriptan;
1 tablet contains 50 mg of sumatriptan in the form of sumatriptan succinate;
Excipients: colloidal anhydrous silica, lactose monohydrate, microcrystalline cellulose, sodium starch glycolate (type A), talc, magnesium stearate.

Dosage form
Coated tablets.

Pharmacological properties
Migranol belongs to a group of drugs used for the treatment of mineraloid attacks. It is used to relieve seizures at various stages.
The main active ingredient, sumatriptan, is a selective agonist of serotonin 5-HT receptors.
Able to influence other five-HT receptors. The latter are found mainly inside the cranial blood vessels.
During research, scientists have established that sumatriptan is capable of producing a selective vasoconstrictor effect on blood vessels involved in the general arterial system of the carotid arteries. At the same time, it has no effect on blood circulation in the brain.
The carotid artery system plays an important role in migraine attacks, since it is their sharp abnormal expansion that leads to the development of mingrenous attacks.
In addition, sumatriptan has the property of influencing the trigeminal nerve, inhibiting its activity, which also contributes to the relief of migraine attacks.

Indications
Migranol is used to quickly relieve migraine attacks.
Effective both with migraine, accompanied by “aura”, and without the latter.
The action begins 30 minutes after taking the standard dose.
Not intended for the prevention of migraine attacks.

Contraindications
The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
Also, use is contraindicated for:

• severe heart disease (myocardial infarction ever in the past, ischemic heart disease, angina pectoris, etc.)
• a stroke or transient cerebrovascular accident in the past;
• arterial hypertension;
• severe liver failure.

Do not use concomitantly with ergotamine or its derivatives, any triptan / 5-hydroxytryptamine receptor (5HT1) agonist, as well as monoamine oxidase inhibitors / use within 2 weeks after stopping their use. Not applicable to persons over 65 years of age.

Children
It is not used in pediatrics.

Application during pregnancy and lactation
This drug is not used in the treatment of pregnant women.
If it is necessary to take the drug during breastfeeding, then lactation should be suspended during treatment.

Method of administration and dosage
It is recommended to use 50 mg as soon as possible after the onset of a migraine attack (in exceptional cases – 100 mg).
At the same time, it is effective regardless of the stage of the attack.
If taking the drug has not had an effect, do not take additional. At the next attack, repeat the dosage (within the next 24 hours), but not more than 300 mg per day.

Overdose
An overdose of 400 mg did not cause side effects.
With a significant overdose, it is theoretically possible to increase side effects.
Symptomatic treatment is recommended – gastric lavage, intake of enterosorbents, monitoring of vital signs, treatment of symptoms.

Side effects
The following side effects are possible:

• dizziness, drowsiness, sensory disturbances, convulsions, tremors, dystonia, nystagmus, scotoma;
• increased blood pressure, hot flashes, bradycardia, tachycardia, rhythm disturbances, transient ischemic ECG changes, spasm of the coronary arteries, angina pectoris, myocardial infarction, hypotension, Raynaud’s disease;
• dyspnea;
• nausea, vomiting, ischemic colitis, diarrhea;
• myalgia, stiff neck muscles, arthralgia;
• pain, feeling of weakness, fatigue;
• hypersensitivity reactions from cutaneous hypersensitivity to cases of anaphylaxis;
• visual impairment, in the form of diplopia, short-term loss of vision (possibly a consequence of the attack itself, and not of taking the drug);
• excitation;
• hyperhidrosis.

Storage conditions and periods
The shelf life is up to 5 years.
The storage temperature of Migranol should not exceed 30 ° C.