Nazik (xylometazoline and dexpanthenol) nasal spray 10 ml.

Description

Nazik composition
The main active ingredients are dexpanthenol and xylometazoline hydrochloride. Also included are auxiliary components, including benzalkonium chloride, potassium dihydrogen phosphate, disodium hydrogen phosphate dodecahydrate, purified water, etc.

Release form
It is produced in the form of a solution for nasal administration, poured into vials with a removable or fixed spray nozzle, 10 ml each, with 1 gram of solution containing 1 mg of xylometazoline and 50 mg of dexpanthenol.

Pharmacological properties
Combined rhinological drug (nasal drops), which belongs to antimicrobial and antiseptic agents for local use.
Consists of a combination of two active ingredients – dexpanthenol (provitamin B5) and xylometazoline.
Once in the skin cells, it quickly turns into pantothenic acid, which is a component of coenzyme, playing an important role in the metabolism of each cell. Pantothenic acid is therefore essential for the protection, formation and healing of damaged skin and mucous membranes.
Xylometazoline produces a vasoconstrictor effect, as a result of which the swelling of the nasal mucosa is eliminated.
One spray allows you to inject 1 ml of the medicinal solution into one of the sinuses.

Indications
Nazik is intended for the treatment of various lesions of the skin and mucous membranes, including:

• nasal congestion during coryza;
• promoting the healing of the skin around the nasal passages and disorders of the mucous membrane in the nasal cavity;
• vasomotor rhinitis;
• nasal breathing disorders after surgical interventions in the nasal cavity.

Dexpanthenol is a derivative of pantothenic acid. It has the ability to regenerate mucous membranes, normalize cell metabolism, accelerate mitosis and strengthen collagen fibers. It has a regenerating, vitaminizing and anti-inflammatory effect.
The body’s need for pantothenic acid increases with damage to the skin or tissues. This shortage can be compensated for with the help of topical application of dexpanthenol, since this substance has the property of intensively penetrating into all layers of the skin.
Xylometazoline hydrochloride, an imidazole derivative, is an alpha-adrenergic sympathomimetic. It has an effect in 5-10 minutes, the manifestation of which is the relief of nasal breathing and improved excretion of secretions.

Contraindications
Not applicable if the patient has hypersensitivity (allergy) to one of the components of the drug.
It is also contraindicated for use if the patient has dry inflammation of the nasal mucosa, acute coronary diseases, including cardiac asthma, hyperthyroidism, angle-closure glaucoma, a history of surgery with exposure of the meninges.
Also, they are not used with concomitant treatment with MAO inhibitors and within two weeks after the end of therapy with this drug.
It is undesirable to use in the case of:

• the use of drugs that increase blood pressure;
• if the patient has increased intraocular pressure;
• the patient suffers from pheochromocytoma;
• the patient suffers from porphyria.

Children
In pediatrics, the children’s form of the drug (from 2 to 6 years old) is used – Nazik for children.

Application during pregnancy and lactation
This drug is not used in any trimester of pregnancy.

Method of administration and dosage
The drug Nazik is intended for topical use.
Apply 1 spray of the drug into each nostril, but no more than 3 times a day, depending on the patient’s individual response to this drug.
When injecting the drug, inhale deeply through the nose.
Do not use the drug for more than 7 days, unless otherwise prescribed by your doctor.
A repeated course can be performed no earlier than after a break of several days and after prior consultation with the attending physician.
In chronic rhinitis, it is permissible to use it only under the supervision of a physician, because of the danger of atrophy of the nasal mucosa.

Overdose
Decongestant sympathomimetics can, with prolonged use or with an overdose, lead to reactive hyperemia of the nasal mucosa.
Exceeding the recommended treatment time can cause chronic swelling of the nasal mucosa and atrophy of the nasal cavity.
Overdose can lead to effects on the central nervous system, causing depression, which can cause:

• cramping;
• bradycardia;
• apnea;
• arterial hypertension;
• arterial hypotension;
• anxiety;
• excitation;
• hallucinations;
• convulsions.

Additional symptoms are also possible, such as miosis, sweating, nausea, cyanosis, tachycardia, cardiac arrest, pulmonary edema, respiratory depression, impaired consciousness.
In case of overdose, the drug should be discontinued. It is recommended to carry out the treatment of symptoms, you should also rinse the stomach, take enterosorbents.

Side effects
Side effects may occur in the form of:

• disorders of the nervous system – excitement, insomnia, drowsiness, headaches;
• from the CCC – tachycardia, increased blood pressure, arrhythmias;
• convulsions, allergic reactions in the form of angioedema, rash, itching;
• discomfort from the nasal mucosa, dryness in the nose, nosebleeds, burning sensations, sneezing.

Storage conditions and periods
Stored for up to 3 years at room temperature not exceeding 20 ° C. After the first use of the bottle, the drug retains its properties for 3 months.