Description

Nebilet Plus Coated Tablets 5 mg/12.5 mg. №28

Ingredients

Nebivolol 5 mg and Hydrochlorothiazide 12.5 mg

Dosage

The usual dose is one tablet daily, preferably in the morning.

Indications

Nebilet Plus is indicated for the treatment of essential hypertension in adults.

Contraindications

Do not use Nebilet Plus if you have severe liver impairment, severe renal impairment, or severe hepatic encephalopathy.

Directions

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Nebilet Plus combines the beta-blocker nebivolol with the diuretic hydrochlorothiazide to provide a dual mechanism of action in lowering blood pressure. Nebivolol acts by blocking beta receptors, leading to decreased heart rate and vasodilation, while hydrochlorothiazide reduces blood volume through diuresis. Clinical studies have shown that this combination is effective in managing hypertension and reducing cardiovascular events.

Additional Information

Nebilet Plus has been well-tolerated in clinical trials with a low incidence of side effects. It is important to monitor blood pressure regularly while taking this medication and consult a healthcare provider for any concerns. This medication should be used as prescribed and not stopped abruptly.

Research has demonstrated that Nebilet Plus is effective not only in lowering blood pressure but also in improving endothelial function and reducing oxidative stress, which are important factors in cardiovascular health. The combination of nebivolol and hydrochlorothiazide offers a comprehensive approach to managing hypertension and its associated risks.