Description

Nimesil (nimesulide) granules 100 mg 2 g. sackets 2g. №30

Ingredients:

Each sachet contains 100 mg of nimesulide.

Dosage:

The recommended dosage for adults is one sachet twice a day. Do not exceed the maximum daily dose of 200 mg.

Indications:

Nimesil is indicated for the treatment of acute pain and inflammation. It is commonly used to relieve symptoms of osteoarthritis, rheumatoid arthritis, and dysmenorrhea.

Contraindications:

Do not use Nimesil if you have a history of allergic reactions to nimesulide or other NSAIDs. Avoid in patients with a history of gastrointestinal bleeding or ulcers.

Directions:

Dissolve the contents of one sachet in a glass of water and drink immediately after a meal. Do not take on an empty stomach.

Scientific Evidence:

Nimesulide, the active ingredient in Nimesil, is a selective COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Studies have shown that nimesulide effectively reduces pain and inflammation in various conditions, including arthritis and acute musculoskeletal disorders. Research published in the Journal of Clinical Pharmacology supports the efficacy of nimesulide in providing rapid and sustained relief from pain.

Additional Information:

Nimesil granules offer a convenient and fast-acting formulation for pain relief. The granules are easy to administer and provide quick absorption, leading to rapid onset of action. It is important to follow the prescribed dosage and duration of treatment to minimize the risk of adverse effects. Consult a healthcare professional before using Nimesil, especially if you have any underlying medical conditions or are taking other medications.

Pharmacological Effects: Nimesulide exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins that cause pain and inflammation. By selectively targeting COX-2, nimesulide reduces inflammation and pain without affecting the protective functions of COX-1 in the stomach lining, thus potentially reducing the risk of gastrointestinal side effects.

Clinical Trials: Clinical trials have demonstrated the efficacy of nimesulide in providing symptomatic relief in various inflammatory conditions. A study published in the European Journal of Clinical Pharmacology found that nimesulide was as effective as other NSAIDs in managing pain and inflammation in patients with osteoarthritis, with a favorable safety profile. Further research is ongoing to explore the long-term safety and effectiveness of nimesulide compared to other NSAIDs.