Nurofen (ibuprofen) coated tablets 200 mg. №12

Description

Nurofen composition
active substance: ibuprofen;
1 film-coated tablet contains ibuprofen 200 mg;
Excipients: croscarmellose sodium, sodium lauryl sulfate, sodium citrate, stearic acid, colloidal anhydrous silica, carmellose sodium, talc, acacia, sucrose, titanium dioxide (E 171), macrogol E000, ink, printing ink 172), propylene glycol (E 1520).

Dosage form
Coated tablets.

Pharmacological properties
Nurofen is a non-steroidal anti-inflammatory drug (NSAID), a derivative of propionic acid, which has been shown to be effective in inhibiting prostaglandin synthesis. In humans, ibuprofen reduces pain in inflammation, edema and fever. In addition, ibuprofen inversely inhibits platelet aggregation.
Nurofen relieves pain, reduces inflammation and lowers fever.

Indication
Symptomatic treatment of headache and toothache, menstrual pain, neuralgia, back pain, joint pain, muscle pain, rheumatic pain, and cold and flu symptoms.

Contraindication:

• Hypersensitivity to ibuprofen or to any of the excipients.
• History of hypersensitivity reactions (eg, asthma, rhinitis, angioneurotic edema, or urticaria) observed with aspirin or other NSAIDs.
• Gastric or duodenal ulcer / bleeding in active form or recurrence in the anamnesis (two or more pronounced episodes of confirmed peptic ulcer disease or bleeding).
• History of gastrointestinal bleeding or perforation associated with NSAID use.
• Severe heart failure (NYHA class IV), severe renal failure or severe hepatic failure.
• The last trimester of pregnancy.
• Active inflammatory bowel disease.
• Hemorrhagic diathesis or other coagulation disorders.

Children
Do not use in children weighing less than 20 kg and under 6 years of age.

Use during pregnancy or breastfeeding
Inhibition of prostaglandin synthesis may adversely affect pregnancy and / or embryo / fetal development.
The drug should not be taken during pregnancy, unless it is absolutely necessary. If Nurofen is used by a woman who is trying to become pregnant or during the first and second trimesters of pregnancy, the lowest possible dose should be used for the shortest period of time.

Method of application and dosage
Nurofen for internal use. For short-term use only. The tablets should be washed down with water, not chewed. During short-term use, if symptoms persist or worsen, the patient should consult a physician.
Side effects can be minimized by applying the lowest effective dose for the shortest period of time required to control symptoms. If symptoms persist for more than 5 days from the start of treatment or worsen, consult a doctor.

• The drug should be prescribed to adults and children weighing more than 20 kg (age – about 6 years). The recommended daily dose of the drug is 20-30 mg / kg body weight. Do not exceed a dose of 30 mg / kg body weight per day.
• Children weighing 20 to 30 kg (aged 6 to 11 years): 200 mg (1 tablet) per reception. Repeat dose if necessary after 6 hours. Do not exceed a dose of 600 mg (3 tablets) per day.
• Adults and children weighing more than 30 kg: 200-400 mg (1-2 tablets) per reception. Repeat dose if necessary after 4-6 hours. Do not exceed a dose of 1200 mg (6 tablets) per day.

Elderly people do not need a special dosage.

Overdose
Most reported overdoses have been asymptomatic. The risk of symptoms occurs when the dose of ibuprofen is more than 80-100 mg / kg. The use of the drug in children at a dose of more than 400 mg / kg may cause symptoms of intoxication. In adults, the effect of the dose is less pronounced. The half-life in overdose is 1.5-3 hours.
Symptoms. Symptoms of overdose occur within 4 hours after application. In most patients, the use of clinically significant amounts of NSAIDs caused symptoms of mild overdose, including nausea, vomiting, epigastric pain, or, less commonly, diarrhea. Tinnitus, headache, and gastrointestinal bleeding may also occur. With more severe poisoning, toxic lesions of the central nervous system are possible, in the form of vertigo, dizziness, lethargy, drowsiness, sometimes – agitation, ataxia, disorientation or coma.
Treatment. There is no specific antidote. Treatment should be symptomatic and supportive, and should include airway patency and monitoring of cardiac function and vital functions until normalization. When using small amounts of the drug (less than 50 mg / kg ibuprofen) it is recommended to use water to minimize the effects of gastrointestinal tact. If large amounts are used, oral administration of activated charcoal or gastric lavage is recommended if no more than 1 hour has elapsed since the patient administered a potentially toxic dose and the patient has not used a life-threatening amount. If ibuprofen has already been absorbed, you can use alkaline substances that promote the excretion of acidic ibuprofen in the urine.

Side effects:

• From the blood system and lymphatic system: hematopoiesis (anemia, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis);
• From the immune system: hypersensitivity reactions; urticaria and itching; severe hypersensitivity reactions, symptoms of which may include swelling of the face, tongue and larynx, dyspnea, tachycardia, hypotension (anaphylactic reaction, angioneurotic edema or severe shock);
• From the nervous system: headache; very rare: aseptic meningitis;
• From the cardiac systems: heart failure, edema;
• From the vascular system: hypertension.
• From the digestive system: abdominal pain, nausea, dyspepsia; diarrhea, flatulence, constipation and vomiting;
• From the liver: liver dysfunction;
• From the skin and subcutaneous tissue: various rashes on the skin;
• From the respiratory tract and mediastinum: airway reactivity, including asthma, bronchospasm or dyspnea;
• From the kidneys and urinary system: acute renal dysfunction.

Expiration date
3 years.

Storage conditions
Keep Nurofen out of the reach of children at a temperature not exceeding 25 ° C.