Nurofen Long (ibuprofen) coated tablets №12

Description

Nurofen Long composition
One tablet contains 200 mg ibuprofen and 500 mg paracetamol.

Release form
Produced in tablet form. It is sold in 6 or 12 tablets in blisters, one blister in a cardboard box.

Pharmacological properties
The main active ingredient of Nurofen Long is ibuprofen, a non-steroidal analgesic anti-inflammatory agent, the effect of which is based on slowing down the synthesis of prostaglandins. The substance inhibits the synthesis of prostaglandins in tissues by suppressing the activity of cyclooxygenase, which stimulates the production of prostaglandins from arachidonic acid.
The mechanism of action of paracetamol is not fully defined, but there is evidence to conclude that it has an analgesic effect on the central nervous system. In addition, biochemical studies indicate that it inhibits the activity of cyclooxygenase in the central nervous system. It was also found that it stimulates the descending pathways of activation of 5-hydroxytryptamine, which helps to inhibit the transmission of pain impulses in the spinal cord.

Indications
Nurofen Long is used for the symptomatic treatment of pain that occurs during menstruation, it is also used to relieve headaches, migraine attacks, back pain, toothache, neuralgia, muscle pain, rheumatic pain, pain associated with mild forms of arthritis. The drug has a more pronounced analgesic effect than its counterparts that do not contain paracetamol.

Contraindications
It can not be prescribed to patients who have been established intolerance to ibuprofen or acetylsalicylic acid, as well as other nonsteroidal anti-inflammatory drugs, manifested by allergic rhinitis, urticaria, bronchial asthma and angioedema. In addition, the drug is not prescribed to patients who suffer from hypersensitivity to paracetamol.
The drug cannot be prescribed to patients who have ulcerative lesions of the intestines or stomach in the acute phase, a predisposition to bleeding from the upper digestive system, or acute renal, hepatic or heart failure.

Children
Not used in pediatrics.

Application during pregnancy and lactation
Pregnancy and lactation are absolute contraindications for the appointment of Nurofen Long

Method of administration and dosage
Nurofen Long is intended to be taken in short courses at the lowest effective dose required to eliminate unwanted symptoms.
Adult patients receive 1 or 2 tablets. The time interval between taking the pills should not be less than 6 hours. The maximum waste dose is 6 tablets.
If taking the drug for 3 days does not lead to a decrease in the severity of the symptoms of the disease, then you should consult a doctor.

Overdose
On the first day, an overdose of paracetamol is manifested by nausea, vomiting, abdominal pain, aversion to food and pallor of the skin. However, after 12 or 48 hours, the patient may experience liver dysfunction, impaired glucose metabolism and metabolic acidosis. In severe forms of poisoning, the development of encephalopathy, hemorrhage, hypoglycemia, coma and death may occur. In rare cases, patients may develop acute renal failure, characterized by acute necrosis of the tubules and manifested by intense low back pain, hematuria and proteinuria. Development of pancreatitis, heart failure and arrhythmias can also be observed.
Treatment consists in quick delivery of the patient to the nearest medical facility.

Side effects
Nurofen Long can cause bronchospasm, nervous excitement, allergic reactions, bleeding from the upper gastrointestinal tract, ulcerative or erosive damage to the digestive system, visual impairment, drowsiness, inflammation of the optic nerve, dyspeptic disorders, headache, angioedema.

Storage conditions and periods
Nurofen Long must be stored in dry, light-protected areas that are completely out of the reach of children. Storage duration is 3 years.