Description

Ortofen (diclofenac) Coated Tablets 25 mg. №30

Ingredients

Active ingredient: Diclofenac sodium 25 mg per tablet.

Dosage

Recommended dosage: The usual dose is 25-50 mg three times a day.

Indications

Ortofen tablets are indicated for the relief of pain and inflammation in conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout.

Contraindications

Do not use Ortofen tablets if you have a history of allergic reactions to diclofenac or other NSAIDs, active peptic ulcer, severe heart failure, or during the third trimester of pregnancy.

Directions

Take Ortofen tablets with a full glass of water. Do not crush or chew the tablets. It is best taken with food to reduce the risk of stomach upset.

Scientific Evidence

Diclofenac, the active ingredient in Ortofen tablets, has been extensively studied for its efficacy in managing pain and inflammation. Research published in the journal *Pain Research and Treatment* showed that diclofenac is effective in reducing pain intensity and improving joint function in patients with osteoarthritis.

Additional Information

Ortofen tablets should be stored at room temperature away from moisture and heat. Keep out of reach of children. If you experience any severe side effects such as black stools, chest pain, or difficulty breathing, seek medical help immediately.

Pharmacological Effects: Diclofenac works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins which are responsible for pain and inflammation. This action helps alleviate symptoms associated with various inflammatory conditions.

Clinical Trials: A randomized controlled trial published in the *Journal of Rheumatology* compared the effectiveness of diclofenac with other NSAIDs in the management of rheumatoid arthritis. The study concluded that diclofenac provided significant pain relief and improved joint function compared to other medications.