Description
Perindopres (perindopril) Tablets 8 mg. №30
Ingredients
- Perindopres tablets contain 8 mg of perindopril as the active ingredient.
Dosage
- The recommended dosage of Perindopres tablets is one 8 mg tablet taken orally once daily.
Indications
- Perindopres tablets are indicated for the treatment of hypertension and heart failure.
Contraindications
- Do not use Perindopres tablets if you are pregnant, have a history of angioedema related to previous ACE inhibitor therapy, or have severe renal impairment.
Directions
- Take Perindopres tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with a glass of water.
Scientific Evidence
- Perindopril, the active ingredient in Perindopres tablets, is an ACE inhibitor that works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion.
- Studies have shown that ACE inhibitors like perindopril are effective in reducing blood pressure and improving outcomes in patients with heart failure.
Additional Information
- It is important to monitor blood pressure regularly while taking Perindopres tablets to ensure optimal control.
- Common side effects may include dizziness, cough, and hyperkalemia.
Pharmacological Effects
- Perindopril, as an ACE inhibitor, blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.
- By inhibiting this enzyme, perindopril helps dilate blood vessels, reduce blood pressure, and improve cardiac function.
- It has been shown to have cardioprotective effects beyond its blood pressure-lowering properties.
Clinical Trials and Comparative Effectiveness
- Clinical trials have demonstrated the efficacy of perindopril in reducing cardiovascular events and mortality in patients with heart failure and post-myocardial infarction.
- Compared to other ACE inhibitors, perindopril has shown similar efficacy but may have a more favorable side effect profile in certain patient populations.
