Description

Pregabalin (Pregabalin) Capsules 75 mg. №21

Ingredients:

Each capsule contains 75 mg of Pregabalin.

Dosage:

The recommended dosage is as prescribed by a healthcare provider. It is typically taken orally, with or without food, usually twice a day.

Indications:

Pregabalin capsules are indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia.

Contraindications:

Do not use Pregabalin if you are allergic to Pregabalin or any of the other ingredients in the capsule. It is important to consult a healthcare provider before starting this medication.

Directions:

Follow the directions provided by your healthcare provider carefully. Do not exceed the recommended dose.

Scientific Evidence:

Pregabalin has been extensively studied for its efficacy in managing neuropathic pain conditions. Research published in the *Journal of Pain Research* has shown that Pregabalin significantly reduces pain intensity and improves quality of life in patients with diabetic neuropathy.

Additional Information:

It is important to note that Pregabalin may cause dizziness and drowsiness. Avoid driving or operating machinery until you know how this medication affects you. Contact your healthcare provider if you experience any severe side effects.

Pharmacological Effects:

Pregabalin exerts its pharmacological effects by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This mechanism reduces the release of neurotransmitters such as glutamate, noradrenaline, and substance P, which are involved in pain signaling pathways.

Clinical Trials and Comparative Effectiveness:

Clinical trials have demonstrated the efficacy of Pregabalin in reducing pain intensity and improving sleep quality in patients with fibromyalgia. Compared to other medications, Pregabalin has shown similar or superior effectiveness in managing neuropathic pain with a favorable side effect profile.

Overall, Pregabalin capsules 75 mg. №21 are a well-established treatment option for neuropathic pain conditions, supported by scientific evidence and clinical trials.