Name: Pregabalin oral solution 20 mg. ml 100 ml. vial buy at Farmasko.com
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$6.00

Indication: Neuropathic pain The drug is indicated for the treatment of neuropathic pain of peripheral or central origin in adults. Epilepsy The drug is indicated for adults as an adjunct treatment for partial seizures with or without secondary generalization. Generalized anxiety disorder The drug is indicated for the treatment of generalized anxiety disorder in adults.

Category: Neurology

Description

Description

Pregabalin Storage
active substance: pregabalin;
1 ml of oral solution contains pregabalin 20 mg;
Excipients: methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), sodium dihydrogen phosphate anhydrous (E 339), sodium hydrogen phosphate anhydrous (E 339), sucralose (E 955), flavor “Strawberry” (contains ethyl acetate and ethylene acetate .

Dosage form
The solution is oral.

Pharmacological properties
The active substance – pregabalin – is an analogue of γ-aminobutyric acid with the chemical name (S) -3- (aminomethyl) -5-methylhexanoic acid.

Mechanism of action
Pregabalin binds to an additional subunit (α2-δ-protein) of potential-dependent calcium channels in the central nervous system (CNS).

Indication:

Neuropathic pain
The drug is indicated for the treatment of neuropathic pain of peripheral or central origin in adults.
Epilepsy
The drug is indicated for adults as an adjunct treatment for partial seizures with or without secondary generalization.
Generalized anxiety disorder
The drug is indicated for the treatment of generalized anxiety disorder in adults.

Contraindication
Hypersensitivity to the active substance or to any of the excipients.

Method of application and dosage
Dosage
The daily dose is 150-600 mg (7.5-30 ml), which is divided into 2-3 doses.
Neuropathic pain
Therapy can be started with a daily dose of 150 mg of pregabalin (7.5 ml), divided into 2-3 doses. Depending on the body’s response and individual tolerability, the daily dose can be increased to 300 mg (15 ml) after 3-7 days. If necessary, after another 7 days, the dose can be increased to a maximum daily dose of 600 mg (30 ml).
Epilepsy
Therapy can be started with a daily dose of 150 mg of pregabalin (7.5 ml), divided into 2-3 doses. Depending on the body’s response and individual tolerability, the daily dose can be increased to 300 mg (15 ml) after 1 week. If necessary, the dose can be increased to a maximum daily dose of 600 mg (30 ml) in a week.
Generalized anxiety disorders
The daily dose is 150-600 mg (7.5-30 ml), divided into 2-3 doses. The need for therapy should be monitored regularly.
Pregabalin therapy can be started with a daily dose of 150 mg pregabalin (7.5 ml). Depending on the clinical response and individual tolerability, the daily dose may be increased to 300 mg (15 ml) after 1 week. After another week, the daily dose can be increased to 450 mg (22.5 ml). In a week the daily dose can be increased to the maximum dose of 600 mg (30 ml).
Withdrawal of pregabalin
In accordance with current clinical practice, it is recommended that the dose be gradually reduced over a period of at least 1 week when pregabalin is discontinued.
Method of reception
The drug can be taken regardless of food intake.
The drug is intended for oral administration only.

Children
Safety and efficacy of the drug in children under 18 years of age have not been established.

Overdose
Adverse reactions to pregabalin overdose reported in post-marketing experience include drowsiness, confusion, agitation, and anxiety. Court attacks have also been reported.
Cases of coma have been reported rarely.
Pregabalin overdose therapy includes general supportive measures, including hemodialysis.

Side effects:

Infections and parasitic infestations: nasopharyngitis;
From the blood and lymphatic system: neutropenia;
From the immune system: hypersensitivity, angioneurotic edema, allergic reactions;
Metabolism and metabolism disorders: increased appetite;
From the psyche: euphoria, confusion, irritability, disorientation, insomnia, decreased libido;
From the nervous system: dizziness, drowsiness, headache, ataxia, incoordination, tremor, dysarthria, amnesia, memory impairment, attention deficit, paresthesia, hypoaesthesia, sedative effect, imbalance, lethargy;
From the eyes: blurred vision, diplopia;
From the organs of hearing and vestibular apparatus: vertigo;
From the heart: tachycardia, atrioventricular block of the 1st degree, sinus bradycardia, heart failure;
From vessels: arterial hypotension, arterial hypertension, hot flashes, reddening of the face, feeling of cold in extremities;
From the respiratory tract, chest and mediastinum: dyspnea, epistaxis, cough, nasal congestion, rhinitis, snoring, dry nose;
From the gastrointestinal tract: vomiting, nausea, constipation, diarrhea, flatulence, bloating, dry mouth;
From the liver and gallbladder: increased levels of liver enzymes;
From the skin and subcutaneous tissue: papular rash, urticaria, hyperhidrosis, itching;
From the musculoskeletal system and connective tissue: muscle cramps, arthralgia, back pain, pain in the extremities, spasms in the neck;
From the kidneys and urinary tract: urinary incontinence, dysuria;
From the genitals and mammary glands: erectile dysfunction.