Reamberin (meglumine sodium succinate) solution for infusions 400 ml. vial

Description

Reamberin (meglumine sodium succinate) solution for infusions 400 ml. vial

Composition

1 ml of solution contains: N-(1-deoxy-D-glucitol-1-yl)-N-methyl ammonium, sodium succinate 0.015 g (15 mg), sodium chloride 0.006 g (6 mg), potassium chloride 0.0003 g ( 0.3 mg), magnesium chloride 0.00012 g (0.12 mg);

excipients: water for injections.

basic physical and chemical properties: transparent, colorless solution;

Release form

Solution for infusions.

Pharmacotherapeutic group

Solutions for intravenous administration.
PBX code В 05Х А 31.

Pharmacological properties

Pharmacological action – detoxification.
Reamberin solution has antihypoxic and antioxidant effects, having a positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring the energy potential of cells.
The drug activates the enzymatic processes of the Krebs cycle and promotes the utilization of fatty acids and glucose by cells, normalizes the acid-base balance and blood gas composition. It has a moderate diuretic effect.

Indications of the drug Reamberin solution

As an antihypoxic agent and detoxification agent for acute intoxications of late etiology:

• hypoxic state of various origins: narcosis, early postoperative period, significant loss of blood pressure, acute heart or respiratory failure, various blood circulation disorders of organs and tissues, microcirculation disorders;
• intoxication of various etiologies: poisoning by xenobiotics or endogenous intoxication;
• shock: hemorrhagic, cardiogenic, burn, traumatic, infectious-toxic;
• complex therapy of toxic hepatitis, cholestasis, protracted forms of viral hepatitis with jaundice.

Method of administration and dosage

Reamberin solution is used only intravenously (drip), in a daily dose (for adults) of up to 2 liters of solution. The rate of administration and dosage of the drug is determined according to the patient’s condition, but no more than 90 drops/min (1-1.5 ml/min),

Adults are usually prescribed 400-800 ml/day. The speed of drug administration and dosage are determined according to the patient’s condition.

In severe forms of shock, hypoxia and intoxication, combination with colloid blood substitutes and other solutions for infusions is recommended.

In case of hepatitis, adults are prescribed a daily dose of 200-400 ml of solution for 2-10 days, depending on the form and severity of the disease, with the control of marker enzymes of liver damage.

Depending on the severity of the disease, the course of treatment is 7–11 days.

Children of the first year of life are administered intravenously at the rate of 2-5 ml/kg of body weight daily once a day. Premature children should be given a solution at a rate of 3-6 ml/h.

Children from 1 to 14 years old are prescribed a daily dose of 10 ml/kg of body weight at a rate of 3-4 ml/min, but no more than 400 ml per day. The dose is divided into 2 administrations.

The duration of the treatment course is 5 days.

Contraindications:

• individual intolerance;
• a condition after a traumatic brain injury, accompanied by cerebral edema;
• severe renal dysfunction;
• pregnancy;
• lactation period.

Side effects:

• With the rapid introduction of the drug, the following side effects are possible.
• General disorders and changes at the injection site: hyperthermia, chills, sweating, weakness, soreness at the injection site, edema, hyperemia, phlebitis.
• From the immune system: allergic reactions, angioedema, anaphylactic shock.
• On the part of the skin and subcutaneous tissue: allergic rash, urticaria, itching.
• Respiratory disorders: shortness of breath, dry cough.
• From the side of the CVS: tachycardia, palpitations, shortness of breath, pain in the heart, pain in the chest.
• Vascular disorders: arterial hypotension / hypertension, short-term reactions in the form of a burning sensation and redness of the upper body.
• From the gastrointestinal tract: nausea, vomiting, metallic taste in the mouth, abdominal pain, diarrhea.
• From the nervous system: dizziness, headache, convulsions, tremors, paresthesias, agitation, anxiety.

In the event of adverse reactions, it is recommended to reduce the rate of drug administration.