Description

Remesulid (nimesulide) tablets 100 mg. №30

Ingredients

Active ingredient: Nimesulide 100 mg per tablet.

Dosage

Recommended dosage: The usual dose is 100 mg twice daily after meals. Do not exceed the recommended dose.

Indications

Remesulid tablets are indicated for the relief of pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders.

Contraindications

Do not use Remesulid tablets if you have a history of hypersensitivity to nimesulide or other NSAIDs, active peptic ulcer, severe heart failure, or renal failure.

Directions

Take Remesulid tablets orally with water after meals. Do not crush or chew the tablets. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Nimesulide, the active ingredient in Remesulid tablets, has been extensively studied for its efficacy in managing pain and inflammation. Research published in the journal Pain and Therapy demonstrated that nimesulide provided significant pain relief in patients with osteoarthritis compared to a placebo group.

Additional Information

It is important to note that prolonged use of nimesulide may increase the risk of adverse effects such as gastrointestinal ulcers and cardiovascular events. Consult your healthcare provider before starting this medication, especially if you have a history of gastrointestinal disorders or cardiovascular disease.

Pharmacological Effects: Nimesulide exerts its pharmacological actions by inhibiting the enzyme cyclooxygenase-2 (COX-2), thereby reducing the production of inflammatory mediators such as prostaglandins. This mechanism helps alleviate pain and inflammation in various conditions.

Clinical Trials: A meta-analysis published in the Journal of Clinical Rheumatology compared the effectiveness of nimesulide with other NSAIDs in the management of rheumatic diseases. The study concluded that nimesulide showed comparable efficacy and safety profiles to other commonly used NSAIDs.