Respix (ambroxol hydrochloride, acetylcysteine) coated tablets №10

Description

Respix (ambroxol hydrochloride, acetylcysteine) coated tablets №10

Composition

active substances: ambroxol hydrochloride, acetylcysteine.

1 tablet contains acetylcysteine ​​200 mg, ambroxol hydrochloride 30 mg;

auxiliary substances: microcrystalline cellulose, povidone, magnesium stearate, lactose monohydrate, sodium starch glycolate, colloidal anhydrous silicon dioxide, hypromellose, talc, polyethylene glycol 6000, titanium dioxide (E 171), dye sunset yellow FCF (E 110).

Medicinal form

Film-coated tablets.

Main physicochemical properties: round, biconvex tablets, covered with a shell, orange in color.

Pharmacotherapeutic group

Means used for coughs and colds. Mucolytic agents. Combinations.
ATX code R05C B10.

Pharmacological properties

Ambroxol is a mucolytic and expectorant, has a pronounced expectorant, anti-inflammatory, immunomodulatory, antioxidant and minor antitussive effect. Stimulates the serous cells of the glands of the mucous membrane of the bronchi, increases the amount of mucous secretion and thus changes the disturbed ratio of serous and mucous components. This normalizes the rheological parameters of sputum, reducing its viscosity and adhesive properties. It directly stimulates the mobile activity of the ciliated epithelium of the bronchi, prevents its sticking and improves the mucociliary evacuation of sputum. Ambroxol increases the content of surfactant in the lungs, and also prevents its destruction by pneumocytes. Ambroxol does not cause broncho-obstruction, but on the contrary, improves the function of external breathing. It has been proven that the drug reduces the hyperreactivity of bronchial muscles in patients with asthma. Ambroxol has an anti-inflammatory effect, antioxidant properties, stimulates local immunity and renewal of the natural surfactant layer. After taking ambroxol, patients’ complaints about cough and sputum are significantly reduced in accordance with the intensity of treatment.

Acetylcysteine ​​is a mucolytic and expectorant. Due to the free sulfhydryl group, it breaks bisulfide bonds of mucopolysaccharides of sputum, which reduces the viscosity of bronchial secretions. Increases mucociliary clearance. Has an antioxidant effect by binding free radicals. Increases the synthesis of glutathione, which is an important factor in detoxification; due to this property, acetylcysteine ​​is used to treat acute poisoning with paracetamol, phenols, aldehydes, and other substances.

Indications

Respix tablets is ​​prescribed as a mucolytic agent for acute / chronic diseases of the bronchopulmonary system, which are accompanied by increased sputum production:

• bronchitis (inflammation of the bronchi);
• bronchiectasis – chronic changes (expansion) of the bronchi;
• chronic obstructive bronchitis;
• bronchial asthma;
• bronchiolitis – inflammation of the small bronchi;
• cystic fibrosis (cystic fibrosis);
• tracheitis – inflammation of the trachea;
• laryngitis – inflammation of the larynx;
• sinusitis – inflammation of the sinuses (sinusitis, sphenoiditis, frontal sinusitis, ethmoiditis, pansinusitis);
• exudative otitis media.

Contraindications

You cannot assign Respix tablets:

• with increased sensitivity to the active ingredient (acetylcysteine);
• with intolerance to the auxiliary components of the drug;
• with peptic ulcer of the stomach / duodenum;
• with the appearance of hemoptysis;
• with pulmonary hemorrhage.
• Respix is ​​used with caution:
• with bronchial asthma;
• with diseases of the digestive system.

Application during pregnancy and lactation

Respix tablets may be used only during these periods only on the recommendation of a doctor. With the use of variables, adverse effects on the mother or fetus, as well as the course of pregnancy, have been demonstrated. When prescribing to a pregnant woman, the doctor must consider the potential risk to the fetus.

Method of administration and dosage

The standard dose of Respix tablets for adults is 1 tablet 3 times / day; for children from 12 years old – the dose is the same as for adults.

The treatment period is determined by the doctor depending on the clinical situation.
The tablets are recommended to be taken after meals.
It is forbidden to mix the ready-made solution with other medicines.
To enhance the mucolytic action, an abundant intake of fluid is recommended.

Overdose

Overdose symptoms: gastrointestinal disturbances (nausea, diarrhea, abdominal pain).
Overdose treatment: temporary cessation of medication, symptomatic therapy.
There is no specific antidote.

Side effects:

• Immune disorders: allergic manifestations, including anaphylactoid reactions, anaphylactic shock, angioedema.
• Neurological disorders: cephalalgia (headache).
• Perceptual disorders: ringing in the ears.
• Cardiac disorders: drop in blood pressure, rapid heartbeat (tachycardia).
• Vascular disorders: hemorrhages.
• Respiratory disorders: bronchospasm, shortness of breath.
• Digestive disorders: dyspepsia, nausea, stomatitis, abdominal pain, vomiting, diarrhea.
• Changes in the skin, its appendages: Stevens-Johnson syndrome, Lyell’s syndrome, rash, edema, urticaria, itching.
• General disorders: edema of the face, hyperthermia.
• Research results: anemia, decreased platelet aggregation.