Retinol acetate (vitamin A) oily oral solution 3.44% 10 ml. vial

Description

Retinol acetate (vitamin A) oily oral solution 3.44% 10 ml. vial

Composition 

active ingredient: retinol acetate (vitamin A-acetate);

1 ml of the drug contains retinol acetate (vitamin A-acetate) in terms of 100% retinol acetate – 34.4 mg (100,000 IU);

excipient: sunflower oil.

Dosage form

Oily oral solution.

Basic physical and chemical properties: transparent oily liquid from light yellow to dark yellow, without rancid taste and smell.

Pharmacological group

Simple preparations of vitamin A. Retinol (vitamin A).
ATC code A11C A01.

Pharmacological properties

Vitamin A (retinol) belongs to the group of fat-soluble vitamins.

Retinol acetate is an analogue of natural vitamin A and is necessary to restore the normal concentration of retinol in the body. Vitamin A plays an important role in the synthesis of proteins, lipids, mucopolysaccharides, regulates the balance of minerals.

The most specific function of vitamin A is to provide visual processes (photoreception). Retinol is involved in the synthesis of visual purple – rhodopsin, located in the rods of the retina.

Vitamin A modulates the processes of differentiation of epithelial cells, participates in the development of secretory glands, keratinization processes, regeneration of mucous membranes and skin.

Vitamin A is necessary for the normal functioning of the endocrine glands and the growth of the body, because it is a synergist of somatomedins.

Vitamin A affects the division of immunocompetent cells, the synthesis of specific factors (immunoglobulin) and non-specific (interferon, lysozyme) protection of the body against infectious and other diseases, stimulates myelopoiesis.

Retinol increases the level of glycogen in the liver, stimulates the production of trypsin and lipase in the digestive system; inhibits photochemical free radical reactions and cysteine ​​oxidation; activates the inclusion of sulfates in the components of connective tissue, cartilage, bones; satisfies the need for sulfocerebrosides and myelin, providing the conduction and transmission of nerve impulses.

With a lack of vitamin A, disorders of twilight vision (night blindness) and atrophy of the epithelium of the conjunctiva, cornea, and lacrimal glands develop. There are degenerative-dystrophic processes in the respiratory tract (mucous membranes of the nasopharynx, paranasal sinuses, trachea, bronchi), in the genitourinary system (epithelium of the renal pelvis, ureters, bladder, urethra, vagina, ovaries, fallopian tubes and endometrium, seminal vesicles and cords, prostate), in the digestive system (mucosa of the digestive tract, salivary glands, pancreas). Vitamin A deficiency leads to a violation of skin trophism (hyperkeratosis), deterioration in the growth and quality of hair and nails, as well as the function of the sebaceous and sweat glands. In addition, there is a decrease in body weight and a slowdown in bone growth, a decrease in the synthesis of glucocorticoids and steroid hormones, a violation of the body’s resistance to infectious and other diseases. There is a tendency to chole- and nephrolithiasis.

A lack or excess of vitamin A in a woman’s body can lead to anomalies in intrauterine development of the fetus.

Retinol has an antitumor effect that does not apply to non-epithelial tumors.

Indications

Retinol acetate is an oil essence that is needed for external or oral administration.
The adaptation of the substance, for the most part, is prescribed for the treatment of vitamin deficiency, ailments of the dermatological integument and eye diseases. In case of skin lesions, it is recommended to apply the substance under a gauze bandage up to 6 times a day. Children over 7 years of age are usually prescribed about 1 -2 drops of the drug orally.

Contraindications

The main danger of using large doses of vitamin A is intoxication of the body, that is, in fact, poisoning. Chronic intoxication is characterized by headaches, nausea, vomiting, indigestion, joint pain. Contraindications to the use of vitamin A are active allergic reactions and hypothyroidism. Also, you can not take retinol preparations together with retinoids, since the combination of these substances increases the toxic effect.

Application during pregnancy and lactation

For women who intend to give birth, vitamin A is of great value as it stimulates postpartum tissue regeneration (in particular, recovery after cesarean section). During pregnancy, it is very important to monitor the amount of renatol intake in the body in order to prevent an excess of vitamin A. Otherwise, the child may develop birth defects and liver damage.

Method of administration and dosage

The drug is taken internally for prophylaxis and treatment within 10-15 minutes after eating. Some time before the introduction, the mixture for injection is heated as close as possible to the temperature of the human body.

Overdose

In large quantities, the substance carries such malignant symptoms as: ataxia, migraine, nausea, vomiting, pain in the bones of the lower extremities. In this case, you should immediately consult a doctor.

Side effects

When taking the medicine in large portions, there is a risk of progression of a chronic vitamin A overdose.
In case of skin diseases, the use of doses higher than the norm of the product, after 7-10 days of treatment, can be accompanied by an exacerbation of the inflammatory reaction, which does not need additional treatment, and in the future it disappears altogether.