Revmoxib (celecoxib) capsules 200 mg. №10

Description

Revmoxib (celecoxib) capsules 200 mg. №10

Composition 

active ingredient: celecoxib;

1 capsule contains celecoxib in terms of 100% substance – 200 mg;

excipients: lactose, monohydrate (granulac-70); povidone; sodium lauryl sulfate; calcium stearate;

composition of the capsule shell: gelatin, titanium dioxide (E 171), azorubine (E 122).

Dosage form

Capsules.

Basic physical and chemical properties: number 0 hard gelatin capsules, white body, pink cap. The contents of the capsules are white or almost white powder.

Pharmacotherapeutic group

Anti-inflammatory and antirheumatic agents. Coxibs.
ATX code M01A H01.

Pharmacological properties

Celecoxib is a non-steroidal anti-inflammatory drug that has demonstrated anti-inflammatory, analgesic, and antipyretic activity in animal models. It is believed that the mechanism of action of the drug is due to the inhibition of prostaglandin synthesis, mainly by inhibiting cyclooxygenase-2 (COX-2); at therapeutic concentrations in humans, it does not inhibit the isoenzyme cyclooxygenase-1 (COX-1). In animal models of colon tumors, celecoxib reduced the incidence and multiplicity of tumors.

Indications

Revmoxib is indicated for degenerative and inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis, etc.).

Contraindications

It is forbidden to use Revmoxib:

• with hypersensitivity to the components of this medication;
• with hyperergic reactions in the past associated with the treatment of NSAIDs;
• with bronchial asthma;
• with exacerbation of duodenal ulcer / stomach ulcer;
• with severe blood clotting disorders;
• with bleeding from the digestive tract;
• with severe heart failure;
• with gastrointestinal bleeding in the past;
• with severe renal / hepatic impairment;
• after coronary artery bypass grafting;
• with severe violations of the heart (heart failure);
• children.

Application during pregnancy and lactation

Contraindicated.

Method of administration and dosage

Revmoxib is used internally (regardless of food), drink plenty of fluids. The standard dosage is 200 mg once or twice a day.
In rheumatoid arthritis, 200-400 mg / day is indicated, divided into 2 doses.

Overdose

In case of an overdose, symptoms such as drowsiness, nausea, and abdominal pain occur. Gastrointestinal bleeding may occur. There is no specific antidote. In case of an overdose in the first four hours, gastric lavage and the use of enterosorbents are indicated. The following shows the maintenance and symptomatic therapy.

Side effects

Side effects that may occur during use include abdominal pain, dizziness, nervousness, blurred vision, shortness of breath, asthma attacks, anemia, various hypersensitivity reactions, arterial hypertension, nausea, tachycardia, malaise, headaches, vomiting, asthenia, hyperkalemia , drowsiness, nightmares, diarrhea, thrombocytopenia (decrease in the number of platelets), constipation, pancytopenia (decrease in the number of all blood cells), fear, purpura, kidney failure, flatulence (bloating), itching, swelling, hypothermia (decrease in temperature), hyperhidrosis (excessive sweating), skin rashes, hot flashes, bronchospasm, jaundice, dyspepsia, erythema, interstitial nephritis, gastritis, dermatitis, stomatitis, angioedema, bleeding from the digestive tract, urticaria, oliguria, ulcer / perforation of the intestine / duodenum / duodenum the appearance of blood in the urine), erythema polyform, facial edema, hepatitis, dysuria, cholestasis, urinary retention (delay urination), Stevens-Johnson syndrome.
If any undesirable reactions occur, the patient should stop taking this medication and contact his doctor.