Revmoxicam (meloxicam) rectal suppositories 15 mg. №5

Description

Revmoxicam (meloxicam) rectal suppositories 15 mg. №5

Composition

active ingredient: meloxicam;

1 suppository contains meloxicam 15 mg;

excipients: solid fat.

Dosage form

Suppositories are rectal.

Basic physical and chemical properties: light yellow suppositories with a greenish tint, cigar-shaped. The presence of plaque on the surface of the suppository is allowed.

Pharmacological group

Nonsteroidal anti-inflammatory and antirheumatic drugs. Meloxicam.
Code ATX M01A C06.

Pharmacological properties

Anti-inflammatory, analgesic, antipyretic. The mechanism of action is due mainly to the selective suppression of cyclooxygenase-2, which leads to inhibition of the biosynthesis of pro-inflammatory prostaglandins in the focus of inflammation. Due to the low affinity for cyclooxygenase-1, the drug in therapeutic doses does not adversely affect the biosynthesis of cytoprotective prostaglandins in the gastrointestinal tract and kidneys, and does not inhibit the functional activity of platelets. It is a chondroneutral drug that does not affect the synthesis of proteoglycan by articular cartilage chondrocytes.

Indications

Revmoxicam rectal suppositories are used for the symptomatic treatment of pain syndrome with:

• ankylosing spondylitis;
• osteoarthritis;
• rheumatoid arthritis.

Contraindications

Revmoxicam rectal suppositories are prohibited in case of hypersensitivity to them or to other NSAIDs.

Also contraindications to the use of Revmoxicam are:

• the presence of ulcers / perforation in the digestive tract;
• blood clotting disorders, bleeding;
• severe liver failure;
• active Crohn’s disease / ulcerative colitis;
• severe renal failure without dialysis;
• past rectal bleeding or proctitis;
• severe uncontrolled heart failure.

Application during pregnancy and lactation

Suppositories Revmoxicam are contraindicated in women during the above periods.

Method of administration and dosage

For adults and children over 16 years of age:

• Exacerbation of osteoarthritis (with insufficient clinical effect of using meloxicam at a dose of 7.5 mg / day): 15 mg / day (1 suppository).
• Rheumatoid arthritis: 15 mg/day (1 suppository).
• Ankylosing spondylitis: 15 mg/day (1 suppository).

The maximum recommended daily dose for adults is 15 mg.

Since the risk of adverse reactions increases with increasing dose and prolonging the duration of treatment, the lowest effective daily dose should be used for the shortest period of treatment.

With the combined appointment of various forms of meloxicam preparations (capsules, tablets, suppositories, solution), the total daily dose should not exceed 15 mg.

Children

The drug is used to treat children from 16 years of age.

Overdose

For acute drug overdose Revmoxicam rectal suppositories is characterized by: drowsiness, abdominal pain, nausea, lethargy, vomiting. Bleeding from the digestive tract is also possible. In severe poisoning, hypertension, liver dysfunction, acute renal failure, cardiac arrest, coma may occur.
Treatment for an overdose with suppositories Revmoxicam involves discontinuing the drug, performing rectal lavage and conducting symptomatic treatment. There is no specific antidote.

Side effects

Side effects that may occur during the use of suppositories Revmoxicam include the following: stomatitis, dizziness, dyspepsia, palpitations, esophagitis, flatulence, headache, swelling, tinnitus, drowsiness, mood changes, conjunctivitis, confusion, visual disturbances, nausea, colitis, increased blood pressure, hot flashes, gastritis, disorientation, gastroduodenal ulcer, acute renal failure, vomiting, photosensitivity, liver dysfunction, abdominal pain, pruritus, belching, gastrointestinal perforation, constipation / diarrhea, skin rashes, bleeding from the digestive tract.

Changes in the blood picture may also occur – thrombocytopenia (a decrease in the number of platelets), leukopenia (a decrease in the number of white blood cells), anemia (a decrease in the number of red blood cells).
Possible anaphylactic reactions, polymorphic erythema, Stevens-Johnson syndrome, angioedema, urticaria.
Patients who are allergic to NSAIDs may develop an asthma attack.
Local side effects against the background of the use of suppositories Revmoxicam include edema, itching or burning in the anorectal region.