Scopril (lisinopril) tablets 10 mg. №30

Description

Scopril (lisinopril) tablets 10 mg. №30

Composition

active ingredient: lisinopril;

1 tablet contains lisinopril 5 mg or 10 mg or 20 mg as lisinopril dihydrate;

excipients: mannitol (E 421), calcium hydrogen phosphate, pregelatinized corn starch, sodium croscarmellose, magnesium stearate; for tablets of 10 mg and 20 mg iron oxide yellow (E 172), iron oxide black (E 172), iron oxide red (E 172).

Dosage form

Tablets.

Basic physical and chemical properties:

• tablets of 5 mg: white, round, biconvex, with a break line on one side;
• tablets of 10 mg: light pink, non-uniformly colored, dotted, round biconvex, with a break line on one side;
• tablets of 20 mg: gray-red, non-uniformly colored, dotted, round, convex, with a break line on one side.

Pharmacological group

Angiotensin-converting enzyme (ACE) inhibitors are simple.
ATX code C09A A03.

Pharmacological properties

It is an antihypertensive (blood pressure lowering) drug that works by inhibiting the renin-angiotensin-aldosterone system. Suppresses the influence of the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin-I into the vasoconstrictor peptide angiotensin-II, preventing its stimulating effect on the secretion of aldosterone by the adrenal glands.

Scopril tablets is used:

• with heart failure (as symptomatic treatment);
• in acute myocardial infarction (for short-term treatment of hemodynamically stable patients);
• with complications from the kidneys (nephropathy) with diabetes mellitus.

Contraindications

Do not use Scopril tablets:

• with intolerance to the components;
• with intolerance to other ACE inhibitors;
• with a history of angioedema;
• with mitral / aortic stenosis or hypertrophic cardiomyopathy with severe hemodynamic disorders;
• with bilateral stenosis of the renal artery (aa. renalis dextra et sinistra) or stenosis of the renal artery (a. renalis) of a single kidney;
• with cardiogenic shock;
• in acute myocardial infarction with unstable hemodynamics;
• with a creatinine level in the blood of 220 μmol / l or more;
• during pregnancy / lactation.

Application during pregnancy and lactation

This medicine is contraindicated in pregnant women, as well as in women planning a pregnancy. Bo II-III trimesters of pregnancy, the drug has fetotoxicity (causes a decrease in renal function, delayed ossification of the skull, oligohydramnios), neonatal toxicity (causes kidney failure, hyperkalemia, arterial hypotension). Not used in nursing mothers.

Method of administration and dosage

Scopril tablets is administered orally (inside).
The dose prescribed by the doctor should be taken once a day, every day at the same time, regardless of food.
The standard initial dose is 2.5–10 mg, the therapeutic dose is 20 mg, and the maximum dose is 80 mg.

Overdose

Symptoms: drop in blood pressure, vascular insufficiency, renal failure, electrolyte imbalance, hyperventilation, palpitations, tachycardia / bradycardia, dizziness, cough, anxiety.
It is necessary to take measures to remove the drug from the body (artificially induce vomiting or rinse the stomach, apply sorbents, sodium sulfate). In case of an overdose, it is recommended to administer saline, angiotensin II and / or catecholamines.
May be cleared by hemodialysis, but metal sulfonate polyacrylonitrile high-throughput membranes (AN69) should be avoided.

Side effects

Possible lymphadenopathy, bone marrow suppression (anemia, thrombocytopenia, leukopenia, agranulocytosis, neutropenia), autoimmune diseases, hemolytic anemia, hypoglycemia, headache, paresthesia, mood changes, vertigo, taste disorders, sleep disturbance, impaired sense of smell, confusion, depression balance disorder, syncope, disorientation, tinnitus, decreased visual acuity, arterial hypotension, fainting, orthostatic effects, myocardial infarction, stroke, palpitations, Raynaud’s syndrome, tachycardia, AV block II, dry cough, bronchospasm, rhinitis, bronchitis, sinusitis , eosinophilic pneumonia / alveolitis, glossitis, diarrhea, abdominal pain, dry mouth, nausea, pancreatitis, hepatocellular / cholestatic hepatitis, liver failure, rash, itching of the skin, alopecia, psoriasis, angioedema, urticaria, dermatitis, urticaria , pseudolymphoma of the skin, polymorphic erythema, fever, arthralgia / arthritis, vasculitis, myalgia, positive anal from ANA, increased ESR, photosensitivity, renal dysfunction, uremia, impotence, acute renal failure, oliguria / anuria, gynecomastia, fatigue, increased levels of urea / creatinine, liver enzymes, bilirubin in the blood, proteinuria, hyperkalemia, hyponatremia.