Soderm (betamethasone) solution for external use 0.1% 15 ml. vial

Description

Soderm (betamethasone) solution for external use 0.1% 15 ml. vial

Composition

active substance: betamethasone;

1 g of solution contains 1.22 mg of betamethasone-17-valerate (corresponds to 1 mg of betamethasone);

Excipients: isopropyl alcohol, polysorbate 80, disodium edetate, dilute hydrochloric acid, purified water.

Dosage form

The solution is dermal.

Basic physical and chemical properties: transparent colorless solution.

Pharmacotherapeutic group

Corticosteroids for use in dermatology. Active corticosteroids (group III). Corticosteroids are potent.
Code ATX D07A C01.

Pharmacological properties

This pharmaceutical agent belongs to corticosteroids, which are intended for use in dermatology.
Specifically, betamethasone is a synthetic fluorinated adrenocorticosteroid that is used topically.
This substance has a high glucocorticosteroid activity, and at the same time – a minimal mineralocorticoid effect. Produces anti-inflammatory, immunosuppressive, antipruritic, antiproliferative and vasoconstrictor effects.
It is a synthetic analogue of prednisolone. Like all corticosteroids, it helps to reduce the release, formation, and activity of chemical elements that mediate the inflammatory process. These include kinins, histamines, lysosomal enzymes, prostaglandins.
It has the property of inhibiting cell migration into the cell, to the damaged site, causing a decrease in vasodilation and increased permeability of veins, arteries and capillaries at the site of injury. As a consequence of this vasoconstrictor effect, extravasation decreases and the likelihood of edema decreases.
Thanks to corticosteroids, the entry of macrophages and some types of T-lymphocytes (sensitized) into the target cells is limited.

Indications

The drug Soderm solution is intended to reduce the symptoms of the inflammatory process in psoriasis and seborrhea of ​​the scalp, allergies or itching in non-infectious diseases of the scalp, the initial stage of severe atopic eczema.

Contraindications

You should not use the specified drug if the patient has had a previous hypersensitivity (allergy) with respect to one of the components that are part of the drug – both basic and auxiliary.
Also contraindicated for:

• rosacea, acne, common plaque psoriasis;
• perianal and genital itching, varicose veins;
• post-vaccination reactions, viral infections (herpes, shingles, chickenpox);
• diaper dermatitis, perioral dermatitis;
• skin manifestations of syphilis, skin tuberculosis;
• other bacterial and fungal skin infections.

Do not use for the treatment of children under 12 months of age.

Application during pregnancy and lactation

Should not be used to treat pregnant women.
During treatment with this drug, breastfeeding should be suspended.

Method of administration and dosage

This drug Soderm solution is used by applying it evenly twice a day to the affected skin.
In mild cases, it is enough to apply the drug once a day or even every other day.
If there are signs of improvement in the condition, it is necessary to reduce the amount of the applied drug.
Make sure that the drug does not get into the eyes! In case of contact with eyes, rinse with water.
The duration of treatment is determined by the attending physician individually, by the attending physician.
Do not cover the affected skin with an occlusive dressing with this drug.

Overdose

Corticosteroid overdose can cause:

• suppression of pituitary-adrenal function;
• secondary insufficiency of the adrenal glands;
• manifestation of symptoms of hypercortisolism, including Cushing’s syndrome.

Recommended symptomatic treatment, gradual withdrawal of the drug.

Side effects

The most common side effects are:

• rash, increased sensitivity, hyperigmentation;
• skin irritation, erythema, itching;
• dry skin, folliculitis, hypertrichosis, acne-like rash;
• hypopigmentation, acne, rosacea-like dermatitis, perioral dermatitis, allergic contact dermatitis;
• maceration of the skin, skin atrophy (when wearing occlusive dressings);
• peeling of the skin, telangiectasia;
• striae, protrusion of blood vessels on the face, with prolonged use of local corticosteroids in this area of ​​the skin;
• insufficiency of the adrenal glands.