Stugeron (cinnarizine) tablets 25 mg. №50

Description

Stugeron (cinnarizine) tablets 25 mg. №50

Composition

active substance: cinnarizine. 1 tablet contains cinnarizine 25 mg;

Excipients: colloidal anhydrous silica, potato starch, magnesium stearate, povidone, talc, corn starch, lactose monohydrate.

Dosage form

Tablets.

Main physical and chemical properties: white or almost white flat, disc-shaped, beveled tablets, practically odorless, engraved with STUGERON on one side and a dash on the other.

Pharmacotherapeutic group

Means used for vestibular disorders. Cinnarizine.
ATX code N07C A02.

Pharmacological properties

It is a blocker of slow calcium channels. The drug reduces the flow of calcium into cells, reducing its content in the plasmolemma depot. At the same time, the tone of smooth muscle fibers of arterioles decreases, the vasodilator effect of carbon dioxide increases.
It also reduces the reaction of blood vessels to nutrients (norepinephrine, adrenaline, dopamine, vasopressin, angiotensin, serotonin). Shows weak antihistamine activity, reduces the excitability of the vestibular apparatus, as well as the tone of the sympathetic nervous system.

Indications

Stugeron is prescribed:

• for the treatment of disorders of cerebrovascular origin (tinnitus, dizziness, irritability, memory loss, concentration, headache);
• with vestibular symptoms (dizziness, nystagmus, nausea of ​​labyrinthine origin, Meniere’s disease, tinnitus);
• for the prevention of “road sickness” (kinetosis), such as motion sickness and air sickness;
  to prevent migraine attacks;
• with violations of peripheral circulation (“intermittent” claudication, paresthesia, diabetic angiopathy, acrocyanosis, night cramps, coldness in the extremities, Raynaud’s disease, thrombophlebitis);
• with trophic disorders (trophic ulcers, varicose ulcers).

Contraindications

Stugeron cannot be prescribed:

• with allergies to components;
• when breastfeeding;
• children under 5 years old.

Stugeron is used with caution in Parkinson’s disease.

Application during pregnancy and lactation

The drug can be prescribed as needed.
There is no data on the penetration of cinnarizine into the mother’s milk, so breastfeeding is stopped.

Method of administration and dosage

Stugeron is used orally (after meals).
Standard dosage:

• for circulatory disorders of the brain, 25-50 mg three times a day are shown;
• for vestibular disorders, 25 mg is shown three times a day;
• in violation of peripheral circulation, 50–75 mg is shown three times a day;
• with kinetosis – 25 mg half an hour before the trip (for adults), if necessary, repeat the intake after 6 hours, maximum – 225 mg / day: for children from 5 to 12 years old – half the adult dose.

The drug can cause drowsiness, so it is recommended to avoid alcohol intake, be careful when taking with drugs that depress the central nervous system.
Due to the fact that the drug has an antihistamine effect, it can affect the results of the anti-doping test in athletes (gives a false-positive result), neutralize positive reactions with skin diagnostic tests (treatment must be canceled 4 days before the study).

Overdose

Symptoms: vomiting, drowsiness, impaired consciousness, tremors, drop in blood pressure.
In case of an overdose, it is required to wash the stomach, and then take activated charcoal.
Treatment is symptomatic.

Side effects:

• Neurological disorders: drowsiness, headache, fatigue, extrapyramidal disorders (increased muscle tone, limb tremor, hypokinesia), depression.
• Digestive disorders: dry mouth, dyspepsia, pain in the supra-gastric region, cholestatic jaundice.
• Changes in the skin: the development of lupus-like syndrome, sweating, lichen planus, skin rash.
• Others: weight gain, allergic reactions.