Sudorega (pregabalin) hard capsules 75 mg. №28

Description

Sudorega (pregabalin) hard capsules 75 mg. №28

Composition

active substance: pregabalin;

1 capsule contains 75 mg or 150 mg of pregabalin;

excipients: lactose monohydrate; corn starch; talc;

capsule shell: gelatin, titanium dioxide (E 171), sodium lauryl sulfate, iron oxide red (E 172) – for a dosage of 75 mg; gelatin, titanium dioxide (E 171), sodium lauryl sulfate – for a dosage of 150 mg.

Dosage form

Hard capsules.

Basic physical and chemical properties:

• 75 mg capsules: white to off-white powder in a “4” hard opaque gelatin capsule with a red lid and a white body with a black “RDY” label on the lid and “293” on the body;
• 150 mg capsules: white to off-white powder in a solid opaque gelatin capsule of size “2” with a white cap and a white body with a black inscription “RDY” on the cap and “295” on the body.

Pharmacotherapeutic group

Antiepileptics. Other antiepileptic drugs.
ATX code N0ZA X16.

Pharmacological properties

This drug Sudorega capsules is included in the group of antiepileptic drugs.
The drug is based on pregabalin, a substance analogous to gamma-aminobutyric acid (also known as aminobutyric acid).
Pregabalin has the ability to bind together with one of the additional subunits found in calcium channels. In turn, calcium channels refer to peripheral sensory neurons, which are part of the nervous system.
As a consequence, pregabalin produces analgesic and anticonvulsant effects.
It has a rapidly developing anxiolytic effect (a stable effect is observed already during the first week of administration), which distinguishes it from other anticonvulsants.
It is also effective as a therapy for neuropathic and chronic pain, anxiety disorders, fibromyalgia, and spinal cord injuries.
Probably the effect of pregabalin on the opioid centers of the central nervous system, as a result of which it is effective in the treatment of opium withdrawal syndrome.

Indications

This drug Sudorega capsules is used to treat:

• peripheral and central neuropathic pain;
• epilepsy, with partial seizures, characterized by both secondary generalization and without it (as an auxiliary drug);
• generalized anxiety disorders, fibromyalgia.

Contraindications

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or one of the auxiliary components.
Not used in pediatrics.

Application during pregnancy and lactation

This drug is contraindicated in the treatment of pregnant women.
If it is necessary to take the drug during breastfeeding, then during treatment, lactation should be suspended.

Method of administration and dosage

The exact dosage is determined by the attending physician, on an individual basis. A certain daily dosage is taken in 2-3 doses, regardless of food intake.
It is recommended to take 150 to 600 mg per day, with a gradual increase in dose, by 150 mg per week.
Refusal to take the drug is also done gradually, in order to avoid “withdrawal syndrome”.
In case of renal failure, the dosage should be reduced.
Old age or hepatic impairment is not an indicator for dose adjustment.

Overdose

Most often, with an overdose, symptoms such as:

• drowsiness, agitation, restlessness;
• loss of consciousness, convulsions;
• coma (isolated cases).

Hemodialysis is recommended to remove excess drug from the body.
Symptomatic treatment is also recommended – gastric lavage, intake of enterosorbents, monitoring of vital signs.

Side effects

The drug can cause side effects in the form of:

• dizziness, drowsiness, headache;
• increased appetite, increase / decrease in body weight;
• nasopharyngitis, euphoria, confusion, irritability, insomnia;
• ataxia, impaired attention, coordination, erection, vision, memory, and also in the form of paresthesia, hypesthesia, lethargy, vertigo;
• vomiting, constipation, flatulence, dry mouth, nausea, diarrhea, heartburn;
• muscle cramps, arthralgia, back pain, limbs;
• edema, fainting, drunkenness, fatigue;
• neutropenia, hypersensitivity;
• anorexia, hypoglycemia;
• agitation, depression, other mental disorders;
• tachycardia, atrioventricular block, sinus bradycardia, congestive heart failure;
• hypotension, hypertension, hot flashes;
• shortness of breath, cough, rhinitis;
• myalgia, urinary incontinence, dysuria, oliguria, renal failure;
• sexual dysfunction;
• ascites, pancreatitis, dysphagia;
• amenorrhea, gynecomastia.