Description
Tingrex (Memantine) Coated Tablets 10 mg. №30
Ingredients
- Active ingredient: Memantine hydrochloride
- Inactive ingredients: Microcrystalline cellulose, colloidal silicon dioxide, talc, magnesium stearate, hypromellose, titanium dioxide, macrogol, iron oxide
Dosage
Recommended dosage: The usual starting dose is 5 mg once daily. The dose is then increased by 5 mg each week up to a maximum of 20 mg per day, taken in divided doses.
Indications
Indicated for: Treatment of moderate to severe Alzheimer’s disease.
Contraindications
Contraindicated in: Patients with known hypersensitivity to memantine or any of the product’s ingredients.
Directions
Administration: Swallow the tablets whole with water, with or without food. Do not crush, chew, or split the tablets.
Scientific Evidence
Memantine, the active ingredient in Tingrex, regulates glutamate activity, aiding cognitive function and slowing Alzheimer’s progression by protecting brain cells from glutamate-induced toxicity.
Additional Information
Monitor renal function in patients taking memantine, especially in those with impaired kidney function. Common side effects include dizziness, headache, and constipation. Consult a healthcare provider for dosage adjustments and potential drug interactions.
Pharmacological Effects
Memantine acts as a low to moderate affinity uncompetitive antagonist at NMDA receptors, regulating glutamate activity to prevent neuronal cell death and excitotoxicity, crucial in managing Alzheimer’s symptoms.
Clinical Trials and Comparative Effectiveness
Memantine improves cognitive function and daily living activities in moderate to severe Alzheimer’s patients. Compared to other medications, it offers similar effectiveness with fewer side effects, making it a valuable treatment option.
Overall, Tingrex (Memantine) Coated Tablets 10 mg. №30 provide a well-tolerated and effective treatment for Alzheimer’s disease, supported by scientific evidence and clinical trials.
