Thiotriazolin (thiazotic acid) solution for injection 2.5% 4 ml. ampoules №10

Description

Thiotriazolin (thiazotic acid) solution for injection 2.5% 4 ml. ampoules №10

Composition

active substance: 1 ml of solution contains morpholinium salt of thiazotic acid in terms of 100% of the substance 25 mg, which is equivalent to 16.6 mg of thiazotic acid

Excipients: water for injections.

Dosage form

Solution for injection.

Main physical and chemical properties: clear colorless or slightly yellowish liquid.

Pharmacotherapeutic group

Cardiac drugs. Other cardiac drugs. Thiazotic acid.
ATC code C01EB23.

Pharmacological properties

It is a remedy that improves metabolic processes. It has anti-ischemic, membrane stabilizing, antioxidant, immunomodulatory effects. The influence of the active component is realized by increasing the compensatory activation of anaerobic glycolysis, activating the oxidation process in the Krebs cycle while maintaining the ATP fund in the cell. It inhibits the processes of fat oxidation in the ischemic area of ​​the heart muscle, reduces its sensitivity to catecholamines, prevents the progression of contraction of the contractile function of the heart, and reduces the zone of myocardial necrosis.

Indications

Thiotriazolin solution is used:

• in the complex treatment of coronary heart disease: myocardial infarction, angina pectoris, postinfarction cardiosclerosis;
• in the complex treatment of cardiac arrhythmias;
• in the complex treatment of chronic hepatitis (cryptogenic, alcoholic), liver fibrosis, liver cirrhosis.

Contraindications

Thiotriazolin solution is contraindicated:

• with intolerance to the components of the drug;
• with severe renal impairment.

Application during pregnancy and lactation

The experience of using Thiotriazolin during these periods is insufficient.

Method of administration and dosage

Thiotriazolin solution is used intramuscularly, intravenously.

• In case of myocardial infarction and unstable angina, Thiotriazolin solution should be administered intravenously slowly in 4 ml of 25 mg / ml solution (100 mg) at a rate of 2 ml / min or intravenously at a rate of 20-30 drops per minute (4 ml of 25 mg / ml solution diluted in 150-250 ml of 0.9% sodium chloride solution) or administered intramuscularly 4 ml of 25 mg / ml solution (100 mg) 2-3 times a day. The course of treatment is 14 days.
• In case of angina pectoris, Thiotriazolin should be administered intramuscularly in 4 ml of 25 mg / ml solution twice a day (daily dose – 200 mg). The course of treatment is 14 days.
• For rest angina and postinfarction cardiosclerosis, Thiotriazolin solution should be administered intramuscularly in 2 ml of 25 mg / ml solution 3 times a day. The course of treatment is 20-30 days.
• In chronic hepatitis with pronounced activity of the process Thiotriazolin solution in the first 5 days to enter intramuscularly 2 ml of 25 mg / ml solution (50 mg) 2-3 times a day or intravenously slowly at a rate of 2 ml / min 4 ml of 25 mg / ml of solution (100 mg) 1 time per day, or dropwise at a rate of 20-30 drops per minute (2 ampoules of 25 mg / ml of solution diluted in 150-250 ml of 0.9% sodium chloride solution). From the 5th to the 20th day of therapy, prescribe Thiotriazolin in tablets (100 mg 3 times a day).
• In case of chronic hepatitis of minimal and moderate degree of activity, Thiotriazolin should be administered intramuscularly in 2 ml of 25 mg / ml solution 3 times a day. The course of treatment is 20-30 days.
• In cirrhosis of the liver, the course of treatment is 60 days. Treatment should be started with intramuscular injection of 2 ml of 25 mg / ml solution (50 mg) 3 times a day for 5 days, and then continue treatment with tablets (100 mg 3 times a day).

Overdose

Signs of an overdose: an increase in the concentration of sodium, potassium in the urine.
In case of an overdose, the drug is canceled, symptomatic treatment is prescribed.

Side effects:

• Cardiovascular disorders: decrease / increase in blood pressure, palpitation, tachycardia.
• Neurological disorders: headaches, tinnitus, dizziness, coordination disorders.
• Digestive disorders: dry mouth, nausea, flatulence, dyspepsia.
• Immune disorders: manifestations of allergies, including skin rashes, urticaria, angioedema, itching.
• Others: choking, shortness of breath, fever, weakness.