Triderm (betamethasone, clotrimazole, gentamicin) cream 15 g. tube

Description

Triderm (betamethasone, clotrimazole, gentamicin) cream 15 g. tube

Composition

active substances: betamethasone, clotrimazole, gentamicin;

1 g of cream contains: betamethasone (in the form of dipropionate) 0.5 mg, clotrimazole 10 mg and gentamicin (in the form of sulfate) 1 mg;

excipients: mineral oil; white soft paraffin; cetostearyl alcohol; propylene glycol; polyethylene glycol cetostearyl ether; benzyl alcohol; sodium dihydrogen phosphate dihydrate; phosphoric acid; sodium hydroxide; purified water.

Dosage form

Cream.

Main physical and chemical properties: soft cream of uniform consistency, white or almost white, free of impurities.

Pharmacotherapeutic group

Corticosteroids for use in dermatology. Corticosteroids in combination with antibiotics. Betamethasone and antibiotics.
ATX code D07C C01.

Pharmacological properties

Triderm cream combines three actions: anti-inflammatory action of betamethasone dipropionate with antibacterial activity of gentamicin sulfate and antifungal action of clotrimazole.

• Betamethasone dipropionate is a potent (class III) corticosteroid with anti-inflammatory, anti-allergic and antipruritic effects.
• Gentamicin is an antibiotic from the group of aminoglycosides with bactericidal action. Inhibits the synthesis of proteins sensitive to antibiotic microorganisms. Gentamicin is active against many aerobic gram-negative and few gram-positive bacteria. In vitro, gentamicin at a concentration of 1–8 μg / ml inhibits most susceptible strains of Escherichia coli, Haemophilus influenzae, Moraxella lacunata, Neisseria, indole-positive and indolenegative strains of Proteus, Pseudomonas (and most of Stasecoccus Staphylococcus aureus . Different species and strains of the same species may show significant differences in in vitro sensitivity. In addition, in vitro sensitivity does not always correlate with in vivo sensitivity. Gentamicin is ineffective against most anaerobic bacteria, fungi and viruses. Gentamicin is only minimally effective against streptococci.
  Gentamicin resistance can develop in gram-negative and gram-positive bacteria.
• Clotrimazole is a synthetic, antifungal agent of the imidazole derivatives group. The range of activities includes a number of fungi that are pathogenic to humans and animals. Clotrimazole is effective against dermatophytes, yeasts and fungi. Efficacy of clotrimazole against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis and Candida (including Candida albicans) has been demonstrated in vitro. Based on current knowledge, the antifungal action of clotrimazole is due to inhibition of ergosterol synthesis. Ergosterol is an important component of the cell membrane of fungi.

Indications

Triderm cream is used in the treatment and prevention of skin dermatoses complicated by infections that are caused by sensitive to the components of the drug microflora. It is used in therapy:

• simple and allergic dermatitis;
• atopic dermatitis, as well as diffuse neurodermatitis;
• limited neurodermatitis;
• eczema;
• dermatomycoses (candidiasis, dermatophytes and herpes zoster);
• acute and chronic herpes.

Contraindications

Triderm is not prescribed to patients with tuberculosis of the skin, cutaneous manifestations of syphilis, herpes simplex virus, chickenpox, open wounds (for ointments) and hypersensitivity to its components. The drug is not prescribed to patients under 2 years of age and skin postvaccination reactions.
Caution should be exercised when prescribing Triderm to pregnant women.

Use during pregnancy and breastfeeding

Triderm should only be used in pregnant women if the intended benefit outweighs the potential risk to the fetus. In the treatment of pregnant women, the drug is used only in minimal doses and for application to small areas of skin.
The drug is able to penetrate into breast milk, so when prescribed to women during lactation, the question of its termination is resolved.

Method of application and dose

Triderm cream should be applied to the affected areas of the body. After squeezing the cream, it is rubbed into the skin area with light massage movements until completely absorbed. The drug is recommended to be applied twice a day. In the treatment of dermatomycoses of the feet, the duration of treatment can reach two, and in some cases even four weeks.
The duration of treatment depends on the severity and location of the infection. If in the process of using Triderm there is no positive dynamics during the disease, it is considered a good reason to clarify the diagnosis.
When using the cream, it is necessary to avoid getting it on the mucous membrane of the eye.

Overdose

With long-term use of Triderm cream in high doses, adrenal dysfunction is possible, accompanied by the development of secondary adrenal insufficiency, which is characterized by the appearance of symptoms of hypercorticism.
With topical application, clotrimazole overdose is not possible.
A single overdose of gentamicin does not lead to the development of any significant symptoms, in case of chronic intoxication with the drug, the growth of resistant flora is possible.
To eliminate the symptoms of hypercorticism, the patient is corrected electrolyte balance and prescribed symptomatic treatment.

Side effects

When using Triderm cream in the areas of its application may develop itching, burning, dry skin, irritation, folliculitis, steroid acne, hypopigmentation and allergic skin reactions.