Description

Uperio (sacubitril, valsartan) Coated Tablets 50 mg. №28

Ingredients

Active ingredients: Sacubitril and valsartan.
Other ingredients: lactose monohydrate, maize starch, crospovidone, colloidal anhydrous silica, magnesium stearate, hypromellose, macrogol 400, titanium dioxide (E171), and iron oxide yellow (E172).

Dosage

Recommended dosage: Take 1 tablet orally twice daily. Do not exceed the recommended dose.

Indications

Uperio tablets are indicated for the treatment of heart failure with reduced ejection fraction.

Contraindications

Do not use Uperio tablets if you are pregnant, breastfeeding, or have a history of angioedema with previous ACE inhibitor or ARB therapy.

Directions

Take Uperio tablets exactly as prescribed by your healthcare provider. Swallow the tablet whole with water, with or without food.

Scientific Evidence

Uperio (sacubitril, valsartan) tablets have shown significant efficacy in reducing cardiovascular mortality and heart failure hospitalizations compared to ACE inhibitors alone. Clinical trials such as the PARADIGM-HF study demonstrated the superiority of sacubitril/valsartan over enalapril in reducing the risk of death and hospitalization in patients with heart failure.

Pharmacologically, sacubitril inhibits neprilysin, leading to increased levels of beneficial peptides, while valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This dual mechanism of action results in improved hemodynamics and reduced cardiac workload.

Additional Information

It is important to monitor blood pressure and renal function regularly while taking Uperio tablets. Inform your healthcare provider about any signs of angioedema, hyperkalemia, or hypotension. Avoid concomitant use of ACE inhibitors with Uperio due to an increased risk of angioedema.

Consult your doctor before starting Uperio tablets, especially if you have a history of kidney or liver problems. Keep the medication out of reach of children and store it at room temperature away from moisture and heat.